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Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid di...

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Bibliographic Details
Main Authors: Hennrich, Marco (Author) , Horn, Patrick (Author) , Eckstein, Volker (Author) , Ye, Fei (Author) , Ding, Ximing (Author) , Poisa-Beiro, Laura (Author) , Luft, Thomas (Author) , Ho, Anthony Dick (Author)
Format: Article (Journal)
Language:English
Published: 01 October 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-06353-4
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1038/s41467-018-06353-4
Verlag, Volltext: https://www.nature.com/articles/s41467-018-06353-4
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Author Notes:Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin & Anthony D. Ho
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Summary:Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.
Item Description:Gesehen am 31.10.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-06353-4

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