Buchumschlag

p120-catenin is essential for terminal end bud function and mammary morphogenesis

Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems reveal markedly different effects. Here, we examine for the first time the consequences of p120 knockout during mouse mammary gland development. An MMTV-Cre driver...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kurley, Sarah J. (VerfasserIn) , Hofmann, Ilse (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 May 2012
In: Development
Year: 2012, Jahrgang: 139, Heft: 10, Pages: 1754-1764
ISSN:1477-9129
DOI:10.1242/dev.072769
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1242/dev.072769
Verlag, Volltext: http://dev.biologists.org/content/139/10/1754
Volltext
Verfasserangaben:Sarah J. Kurley, Brian Bierie, Robert H. Carnahan, Nichole A. Lobdell, Michael A. Davis, Ilse Hofmann, Harold L. Moses, William J. Muller and Albert B. Reynolds

MARC

LEADER 00000caa a2200000 c 4500
001 1582525935
003 DE-627
005 20220815044732.0
007 cr uuu---uuuuu
008 181102s2012 xx |||||o 00| ||eng c
024 7 |a 10.1242/dev.072769  |2 doi 
035 |a (DE-627)1582525935 
035 |a (DE-576)512525935 
035 |a (DE-599)BSZ512525935 
035 |a (OCoLC)1341022171 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Kurley, Sarah J.  |e VerfasserIn  |0 (DE-588)1170443044  |0 (DE-627)1039278027  |0 (DE-576)512525641  |4 aut 
245 1 0 |a p120-catenin is essential for terminal end bud function and mammary morphogenesis  |c Sarah J. Kurley, Brian Bierie, Robert H. Carnahan, Nichole A. Lobdell, Michael A. Davis, Ilse Hofmann, Harold L. Moses, William J. Muller and Albert B. Reynolds 
264 1 |c 15 May 2012 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 02.11.2018 
520 |a Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems reveal markedly different effects. Here, we examine for the first time the consequences of p120 knockout during mouse mammary gland development. An MMTV-Cre driver was used to target knockout to the epithelium at the onset of puberty. p120 ablation was detected in approximately one-quarter of the nascent epithelium at the forth week post-partum. However, p120 null cells were essentially nonadherent, excluded from the process of terminal end bud (TEB) morphogenesis and lost altogether by week six. This elimination process caused a delay in TEB outgrowth, after which the gland developed normally from cells that had retained p120. Mechanistic studies in vitro indicate that TEB dysfunction is likely to stem from striking E-cadherin loss, failure of cell-cell adhesion and near total exclusion from the collective migration process. Our findings reveal an essential role for p120 in mammary morphogenesis. 
700 1 |a Hofmann, Ilse  |d 1961-  |e VerfasserIn  |0 (DE-588)1026722276  |0 (DE-627)727104764  |0 (DE-576)372016251  |4 aut 
773 0 8 |i Enthalten in  |t Development  |d Cambridge : The Company of Biologists, 1987  |g 139(2012), 10, Seite 1754-1764  |h Online-Ressource  |w (DE-627)31982439X  |w (DE-600)2007916-3  |w (DE-576)090893131  |x 1477-9129  |7 nnas  |a p120-catenin is essential for terminal end bud function and mammary morphogenesis 
773 1 8 |g volume:139  |g year:2012  |g number:10  |g pages:1754-1764  |g extent:11  |a p120-catenin is essential for terminal end bud function and mammary morphogenesis 
856 4 0 |u http://dx.doi.org/10.1242/dev.072769  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://dev.biologists.org/content/139/10/1754  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20181102 
993 |a Article 
994 |a 2012 
998 |g 1026722276  |a Hofmann, Ilse  |m 1026722276:Hofmann, Ilse  |d 60000  |d 999810  |e 60000PH1026722276  |e 999810PH1026722276  |k 0/60000/  |k 1/60000/999810/  |p 6 
999 |a KXP-PPN1582525935  |e 3030230112 
BIB |a Y 
SER |a journal 
JSO |a {"title":[{"title_sort":"p120-catenin is essential for terminal end bud function and mammary morphogenesis","title":"p120-catenin is essential for terminal end bud function and mammary morphogenesis"}],"person":[{"given":"Sarah J.","family":"Kurley","role":"aut","display":"Kurley, Sarah J.","roleDisplay":"VerfasserIn"},{"given":"Ilse","family":"Hofmann","role":"aut","roleDisplay":"VerfasserIn","display":"Hofmann, Ilse"}],"language":["eng"],"recId":"1582525935","note":["Gesehen am 02.11.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1582525935"],"doi":["10.1242/dev.072769"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"15 May 2012"}],"name":{"displayForm":["Sarah J. Kurley, Brian Bierie, Robert H. Carnahan, Nichole A. Lobdell, Michael A. Davis, Ilse Hofmann, Harold L. Moses, William J. Muller and Albert B. Reynolds"]},"relHost":[{"titleAlt":[{"title":"Development <Cambridge>"}],"part":{"text":"139(2012), 10, Seite 1754-1764","volume":"139","extent":"11","year":"2012","pages":"1754-1764","issue":"10"},"pubHistory":["Volume 99, 1 (January 1987)-"],"corporate":[{"role":"isb","display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"recId":"31982439X","disp":"p120-catenin is essential for terminal end bud function and mammary morphogenesisDevelopment","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 26.06.2025"],"title":[{"title_sort":"Development","title":"Development"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1477-9129"],"zdb":["2007916-3"],"eki":["31982439X"]},"origin":[{"publisher":"The Company of Biologists","dateIssuedKey":"1987","dateIssuedDisp":"1987-","publisherPlace":"Cambridge"}],"name":{"displayForm":["Company of Biologists"]}}],"physDesc":[{"extent":"11 S."}]} 
SRT |a KURLEYSARAP120CATENI1520 

Ähnliche Einträge