Differential requirements in endocytic trafficking for penetration of dengue virus
The entry of DENV into the host cell appears to be a very complex process which has been started to be studied in detail. In this report, the route of functional intracellular trafficking after endocytic uptake of dengue virus serotype 1 (DENV-1) strain HW, DENV-2 strain NGC and DENV-2 strain 16681...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 7, 2012
|
| In: |
PLOS ONE
Year: 2012, Jahrgang: 7, Heft: 9 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0044835 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1371/journal.pone.0044835 Verlag, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044835 
|
| Verfasserangaben: | Eliana G. Acosta, Viviana Castilla, Elsa B. Damonte |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1582552827 | ||
| 003 | DE-627 | ||
| 005 | 20230427193237.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181105s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0044835 |2 doi | |
| 035 | |a (DE-627)1582552827 | ||
| 035 | |a (DE-576)512552827 | ||
| 035 | |a (DE-599)BSZ512552827 | ||
| 035 | |a (OCoLC)1341021978 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Acosta, Eliana G. |e VerfasserIn |0 (DE-588)106006622X |0 (DE-627)799209783 |0 (DE-576)416170692 |4 aut | |
| 245 | 1 | 0 | |a Differential requirements in endocytic trafficking for penetration of dengue virus |c Eliana G. Acosta, Viviana Castilla, Elsa B. Damonte |
| 264 | 1 | |c September 7, 2012 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.12.2018 | ||
| 520 | |a The entry of DENV into the host cell appears to be a very complex process which has been started to be studied in detail. In this report, the route of functional intracellular trafficking after endocytic uptake of dengue virus serotype 1 (DENV-1) strain HW, DENV-2 strain NGC and DENV-2 strain 16681 into Vero cells was studied by using a susceptibility to ammonium chloride assay, dominant negative mutants of several members of the family of cellular Rab GTPases that participate in regulation of transport through endosome vesicles and immunofluorescence colocalization. Together, the results presented demonstrate that in spite of the different internalization route among viral serotypes in Vero cells and regardless of the viral strain, DENV particles are first transported to early endosomes in a Rab5-dependent manner. Then a Rab7-dependent pathway guides DENV-2 16681 to late endosomes, whereas a yet unknown sorting event controls the transport of DENV-2 NGC, and most probably DENV-1 HW, to the perinuclear recycling compartments where fusion membrane would take place releasing nucleocapsid into the cytoplasm. Besides the demonstration of a different intracellular trafficking for two DENV-2 strains that shared the initial clathrin-independent internalization route, these studies proved for the first time the involvement of the slow recycling pathway for DENV-2 productive infection. | ||
| 650 | 4 | |a Chlorides | |
| 650 | 4 | |a Cytoplasm | |
| 650 | 4 | |a Endosomes | |
| 650 | 4 | |a Immunofluorescence | |
| 650 | 4 | |a Membrane fusion | |
| 650 | 4 | |a Vero cells | |
| 650 | 4 | |a Vesicles | |
| 650 | 4 | |a Virions | |
| 700 | 1 | |a Castilla, Viviana |e VerfasserIn |0 (DE-588)1172814856 |0 (DE-627)1041816774 |0 (DE-576)51255269X |4 aut | |
| 700 | 1 | |a Damonte, Elsa B. |e VerfasserIn |0 (DE-588)1172814988 |0 (DE-627)1041816979 |0 (DE-576)512552711 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 7(2012), 9, Artikel-ID e44835 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Differential requirements in endocytic trafficking for penetration of dengue virus |
| 773 | 1 | 8 | |g volume:7 |g year:2012 |g number:9 |g elocationid:e44835 |g extent:13 |a Differential requirements in endocytic trafficking for penetration of dengue virus |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0044835 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044835 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181105 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 106006622X |a Acosta, Eliana G. |m 106006622X:Acosta, Eliana G. |p 1 |x j | ||
| 999 | |a KXP-PPN1582552827 |e 3030372545 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"13 S."}],"relHost":[{"title":[{"title_sort":"PLOS ONE","title":"PLOS ONE"}],"pubHistory":["1.2006 -"],"part":{"year":"2012","issue":"9","text":"7(2012), 9, Artikel-ID e44835","volume":"7","extent":"13"},"disp":"Differential requirements in endocytic trafficking for penetration of dengue virusPLOS ONE","note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"Public Library of Science"}],"recId":"523574592","origin":[{"publisher":"PLOS ; PLoS","dateIssuedKey":"2006","dateIssuedDisp":"2006-","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"id":{"issn":["1932-6203"],"eki":["523574592"],"zdb":["2267670-3"]},"name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Eliana G. Acosta, Viviana Castilla, Elsa B. Damonte"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"September 7, 2012"}],"id":{"doi":["10.1371/journal.pone.0044835"],"eki":["1582552827"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 05.12.2018"],"recId":"1582552827","language":["eng"],"person":[{"given":"Eliana G.","family":"Acosta","role":"aut","roleDisplay":"VerfasserIn","display":"Acosta, Eliana G."},{"role":"aut","display":"Castilla, Viviana","roleDisplay":"VerfasserIn","given":"Viviana","family":"Castilla"},{"family":"Damonte","given":"Elsa B.","roleDisplay":"VerfasserIn","display":"Damonte, Elsa B.","role":"aut"}],"title":[{"title_sort":"Differential requirements in endocytic trafficking for penetration of dengue virus","title":"Differential requirements in endocytic trafficking for penetration of dengue virus"}]} | ||
| SRT | |a ACOSTAELIADIFFERENTI7201 | ||