Efficacy of exercise training in pulmonary arterial hypertension associated with congenital heart disease
Background: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH). Methods: Patients with invasively confirmed CHD-APAH received in-hospital...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 September 2013
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| In: |
International journal of cardiology
Year: 2013, Jahrgang: 168, Heft: 1, Pages: 375-381 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2012.09.036 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijcard.2012.09.036 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167527312011424 
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| Verfasserangaben: | Tabea Becker-Grünig, Hans Klose, Nicola Ehlken, Mona Lichtblau, Christian Nagel, Christine Fischer, Matthias Gorenflo, Henning Tiede, Dietmar Schranz, Alfred Hager, Harald Kaemmerer, Oliver Miera, Silvia Ulrich, Rudolf Speich, Sören Uiker, Ekkehard Grünig |
| Zusammenfassung: | Background: The objective of this prospective study was to assess the efficacy of exercise training as add-on to medical therapy in patients with congenital heart disease associated pulmonary arterial hypertension (CHD-APAH). Methods: Patients with invasively confirmed CHD-APAH received in-hospital exercise training for 3weeks and continued at home. Efficacy parameters were evaluated at baseline, after 3 and 15weeks. Medical treatment remained unchanged. Worsening events and survival rate were assessed in a follow-up period of 21±14months. Results: Twenty consecutive CHD-APAH patients (16 female, 4 male, mean pulmonary arterial pressure 60±23mmHg) were included. Patients significantly improved the mean distance walked in 6min compared to baseline by 63±47m after 3weeks (p<0.001) and by 67±59m after 15weeks (p=0.001). Quality of life-score (p=0.05), peak oxygen consumption (p=0.002) and maximal workload (p=0.003) improved significantly by exercise training after 15weeks. The 1- and 2‐year survival rates were 100%, the transplantation-free survival rate was 100% after 1year and 93% after 2years. Conclusion: Exercise training as add-on to medical therapy may be effective in patients with CHD-APAH and improved work capacity, quality of life and further prognostic relevant parameters. It was associated with an excellent long-term survival. Further randomized controlled studies are needed to confirm these results. |
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| Beschreibung: | Available online 5 October 2012 Gesehen am 05.11.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2012.09.036 |