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Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph

Background: We have recently reported from Epilymph, a multicentre case-control study of lymphoma conducted in six European countries, a significant association between NHL and self-reported history of past or present HBV infection based on questionnaire data from face-to-face interviews. Methods: T...

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Main Authors: Becker, Nikolaus (Author) , Schnitzler, Paul (Author) , Nieters, Alexandra (Author)
Format: Article (Journal)
Language:English
Published: 06 July 2012
In: Journal of cancer research and clinical oncology
Year: 2012, Volume: 138, Issue: 12, Pages: 1993-2001
ISSN:1432-1335
DOI:10.1007/s00432-012-1279-y
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00432-012-1279-y
Verlag, Volltext: https://doi.org/10.1007/s00432-012-1279-y
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Author Notes:Nikolaus Becker, Paul Schnitzler, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadié, Alexandra Nieters, Anthony Staines, Yolanda Benavente, Pierluigi Cocco, Silvia de Sanjose

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245 1 0 |a Hepatitis B virus infection and risk of lymphoma  |b results of a serological analysis within the European case-control study Epilymph  |c Nikolaus Becker, Paul Schnitzler, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadié, Alexandra Nieters, Anthony Staines, Yolanda Benavente, Pierluigi Cocco, Silvia de Sanjose 
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520 |a Background: We have recently reported from Epilymph, a multicentre case-control study of lymphoma conducted in six European countries, a significant association between NHL and self-reported history of past or present HBV infection based on questionnaire data from face-to-face interviews. Methods: To corroborate this observation, we used the data and blood specimen from Epilymph to investigate the associations between serological indicators of HBV infection with risk of Hodgkin lymphoma, non-Hodgkin lymphoma (NHL) and specific lymphoma entities. For 1,518 cases and 1,496 controls with sufficient amount of serum or plasma, we tested HBs-antigen, anti-HBc and anti-HBs to distinguish between current or past infection and immunity by vaccination. Statistical analysis was carried out with unconditional logistic regression. Results: We found a positive association of a past HBV infection with multiple myeloma (MM, OR = 1.97, 95 % CL = 1.16-3.37). Non-significant associations were found between past HBV infection and B-cell chronic lymphocytic leukaemia (B-CLL, OR = 1.33, 95 % CL = 0.82-2.16) and T-cell NHL (OR = 1.59, 95 % CL = 0.65-3.90), as well as between current HBV infection and NHL (OR = 1.49, 95 % CL = 0.65-3.41), B-NHL (OR = 1.58, 95 % CL = 0.69-3.64) and diffuse large B-cell lymphoma (DLBCL, OR = 1.50, 95 % CL = 0.47-4.82). Subjects having self-reported HBV infection were serological positive in 75 % of cases and 80 % of controls. For vaccination, the corresponding figures were 49 and 54 %, respectively. Conclusion: The present results support previous reports of an association between a history of HBV infection with an elevated lymphoma risk and add multiple myeloma to the list of potentially virus-associated lymphoma entities. 
650 4 |a B-NHL 
650 4 |a Chronic lymphocytic leukaemia 
650 4 |a Diffuse large B-cell lymphoma 
650 4 |a Follicular lymphoma 
650 4 |a Multiple myeloma 
650 4 |a NHL 
650 4 |a T-cell lymphoma 
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700 1 |a Nieters, Alexandra  |e VerfasserIn  |0 (DE-588)1075504325  |0 (DE-627)833361686  |0 (DE-576)173179126  |4 aut 
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