Targeting the lateral but not the third ventricle induces bone loss in ewe: an experimental approach to generate an improved large animal model of osteoporosis
Osteoporosis is a chronic disease characterized by bone loss and increased skeletal fragility. Large animal models are required for preclinical testing of new therapeutic approaches. We have recently demonstrated that continuous intracerebroventricular (ICV) application of leptin into the lateral ve...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 1, 2012
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| In: |
The journal of trauma and acute care surgery
Year: 2012, Jahrgang: 72, Heft: 3, Pages: 720-726 |
| ISSN: | 2163-0763 |
| DOI: | 10.1097/TA.0b013e318238b3bd |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1097/TA.0b013e318238b3bd Verlag, Volltext: https://journals.lww.com/jtrauma/fulltext/2012/03000/Targeting_the_lateral_but_not_the_third_ventricle.26.aspx 
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| Verfasserangaben: | Ralf Oheim, Frank Timo Beil, Florian Barvencik, Marcus Egermann, Michael Amling, Iain J. Clarke, and Pia Pogoda |
MARC
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| 520 | |a Osteoporosis is a chronic disease characterized by bone loss and increased skeletal fragility. Large animal models are required for preclinical testing of new therapeutic approaches. We have recently demonstrated that continuous intracerebroventricular (ICV) application of leptin into the lateral ventricle (LV) induces bone loss in ewe. On the basis of these findings, we reasoned that the third ventricle (TV) is an even better target because of its closer location to the hypothalamus that mediates leptin effects on bone. | ||
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