Sample sizes for time-to-event endpoints: should you insure against chance variations in accrual?

This note addresses the questions of whether one should safeguard against a potential loss of power due to random variations of the accrual time, how this “insurance” can be formulated, and how much the sample size needs to be increased to obtain it.

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Bibliographische Detailangaben
Hauptverfasser: Abel, Ulrich (VerfasserIn) , Jensen, Katrin (VerfasserIn) , Karapanagiotou-Schenkel, Irini (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: March 2012
In: Contemporary clinical trials
Year: 2012, Jahrgang: 33, Heft: 2, Pages: 456-458
ISSN:1559-2030
DOI:10.1016/j.cct.2011.10.009
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.cct.2011.10.009
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1551714411002667
Volltext
Verfasserangaben:Ulrich R. Abel, Katrin Jensen, Irini Karapanagiotou-Schenkel

MARC

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