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Structural effects and lipid membrane interactions of the pH-responsive GALA peptide with fatty acid acylation

GALA is a pH-responsive, membrane-perturbing peptide designed to fold from a random coil at physiological pH to an amphipathic α-helix under mildly acidic conditions. Because of its pH-activated function, GALA has been sought-after as a component of intracellular drug delivery systems that could act...

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Bibliographic Details
Main Authors: Lin, Brian (Author) , Missirlis, Dimitris (Author)
Format: Article (Journal)
Language:English
Published: 12 June 2012
In: Biochemistry
Year: 2012, Volume: 51, Issue: 23, Pages: 4658-4668
ISSN:1520-4995
DOI:10.1021/bi300314h
Online Access:Verlag, Volltext: http://dx.doi.org/10.1021/bi300314h
Verlag, Volltext: https://pubs.acs.org/doi/full/10.1021/bi300314h
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Author Notes:Brian F. Lin, Dimitris Missirlis, Daniel V. Krogstad, and Matthew Tirrell

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