Arterial spin labeling at 3.0 Tesla in subacute ischemia: comparison to dynamic susceptibility perfusion
PurposeArterial spin labeling (ASL) is a promising but clinically not established non-invasive method to assess cerebral perfusion. The purpose of this study was to compare perfusion imaging with pulsed ASL (pASL) to conventional dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWL)...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2012
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| In: |
Clinical neuroradiology
Year: 2012, Volume: 22, Issue: 1, Pages: 29-37 |
| ISSN: | 1869-1447 |
| DOI: | 10.1007/s00062-011-0126-x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00062-011-0126-x Verlag, Volltext: https://doi.org/10.1007/s00062-011-0126-x 
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| Author Notes: | S. Huck, H.U. Kerl, M. Al-Zghloul, C. Groden, I. Nölte |
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| 245 | 1 | 0 | |a Arterial spin labeling at 3.0 Tesla in subacute ischemia |b comparison to dynamic susceptibility perfusion |c S. Huck, H.U. Kerl, M. Al-Zghloul, C. Groden, I. Nölte |
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| 520 | |a PurposeArterial spin labeling (ASL) is a promising but clinically not established non-invasive method to assess cerebral perfusion. The purpose of this study was to compare perfusion imaging with pulsed ASL (pASL) to conventional dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWL) using commercially available equipment and postprocessing (3.0 Tesla, 32-channel head coil) in patients with subacute ischemia.MethodsThe pASL and DSC-PWI techniques were compared in 15 patients with subacute ischemia (age 49-88 years, 6 females and 9 males, time from onset to scan 4-161 h). Image inhomogeneity was assessed with the non-uniformity index. Image quality, delineation of hypoperfusion and degree of hypoperfusion were rated by two readers using a 5-scale grading system. The volume of hypoperfusion was quantified planimetrically.ResultsImage quality and image inhomogeneity were superior in DSC time-to-peak (TTP) compared to pASL cerebral brain flow (CBF; both p < 0.05). The delineation of hypoperfusion was better in DSC-TTP (p < 0.05) and the hypoperfusion was graded as more severe in DSC-TTP (p < 0.05). The volume of hypoperfusion did not differ between pASL-CBF and DSC-TTP, however, in pASL-CBF five cases with small infarctions (lacunar and pontine) were false negative compared to DSC-relative CBF. The mismatch frequency was lower in pASL (13%) than in DSC-rCBF (20%) and DSC-TTP (47%).ConclusionsUsing a commercially available sequence and a 32-channel head coil at 3.0 Tesla pASL-CBF is feasible but limited compared to DSC-PWI in the assessment of ischemic stroke. In its present form pASL has a reserve role in clinical practice for situations when gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) is contraindicated. | ||
| 650 | 4 | |a Arterial spin labeling (ASL) | |
| 650 | 4 | |a Cerebral perfusion | |
| 650 | 4 | |a Dynamic susceptibility imaging | |
| 650 | 4 | |a Magnetic resonance imaging (MRI) | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a Subacute ischemia | |
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