Impact of small molecules on β-catenin and E-cadherin expression in HPV16-positive and -negative squamous cell carcinomas
Background: The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib,...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2017
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| In: |
Anticancer research
Year: 2017, Jahrgang: 37, Heft: 6, Pages: 2845-2852 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.11636 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.11636 Verlag, Volltext: http://ar.iiarjournals.org/content/37/6/2845 
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| Verfasserangaben: | Benedikt Kramer, Clemens Hock, Johannes David Schultz, Anne Lammert, Beatrice Kuhlin, Richard Birk, Karl Hörmann and Christoph Aderhold |
MARC
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| 520 | |a Background: The validation of potential molecular targets in head and neck squamous cell carcinoma (SCC) is mandatory. β-Catenin and E-cadherin are crucial for cancer progression through epithelial-mesenchymal transition. We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on β-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. Materials and Methods: Expression of β-catenin and E-cadherin in cell lines UMSCC 11A, UMSCC 14C and CERV196 under the influence of tyrosine kinase inhibitors were analyzed by enzyme-linked immunosorbent assay. Results: All agents reduced β-catenin and E-cadherin expression of HPV16-negative cells. Increased E-cadherin expression was observed after treatment with gefitinib and dasatinib in HPV16-positive cells. Conclusion: All substances, nilotinib, dasatinib, erlotinib and gefitinib have a significant impact on β-catenin and E-cadherin expression in both HPV16-positive and HPV16-negative cells in vitro. Alterations of β-catenin and E-cadherin could provide novel insights for future targeted therapies of head and neck SCC. | ||
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