HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling
Burkitt lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is e...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2, 2017
|
| In: |
Blood
Year: 2017, Jahrgang: 129, Heft: 5, Pages: 598-608 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2016-06-721423 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1182/blood-2016-06-721423 Verlag, Volltext: http://www.bloodjournal.org/content/129/5/598 
|
| Verfasserangaben: | Roland Walter, Kuan-Ting Pan, Carmen Doebele, Federico Comoglio, Katarzyna Tomska, Hanibal Bohnenberger, Ryan M. Young, Laura Jacobs, Ulrich Keller, Halvard Bönig, Michael Engelke, Andreas Rosenwald, Henning Urlaub, Louis M. Staudt, Hubert Serve, Thorsten Zenz, Thomas Oellerich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1583697888 | ||
| 003 | DE-627 | ||
| 005 | 20220815053612.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181114s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2016-06-721423 |2 doi | |
| 035 | |a (DE-627)1583697888 | ||
| 035 | |a (DE-576)513697888 | ||
| 035 | |a (DE-599)BSZ513697888 | ||
| 035 | |a (OCoLC)1341023554 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Walter, Roland |d 1984- |e VerfasserIn |0 (DE-588)1189104997 |0 (DE-627)1667853090 |0 (DE-576)513698531 |4 aut | |
| 245 | 1 | 0 | |a HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling |c Roland Walter, Kuan-Ting Pan, Carmen Doebele, Federico Comoglio, Katarzyna Tomska, Hanibal Bohnenberger, Ryan M. Young, Laura Jacobs, Ulrich Keller, Halvard Bönig, Michael Engelke, Andreas Rosenwald, Henning Urlaub, Louis M. Staudt, Hubert Serve, Thorsten Zenz, Thomas Oellerich |
| 264 | 1 | |c February 2, 2017 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First edition: November 15, 2016 | ||
| 500 | |a Gesehen am 14.11.2018 | ||
| 520 | |a Burkitt lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is endemic. Targeted therapies for BL are therefore needed. In this study, we performed a compound screen in 17 BL cell lines to identify small molecule inhibitors affecting cell survival. We found that inhibitors of heat shock protein 90 (HSP90) induced apoptosis in BL cells in vitro at concentrations that did not affect normal B cells. By global proteomic and phosphoproteomic profiling, we show that, in BL, HSP90 inhibition compromises the activity of the pivotal B-cell antigen receptor (BCR)-proximal effector spleen tyrosine kinase (SYK), which we identified as an HSP90 client protein. Consistently, expression of constitutively active TEL-SYK counteracted the apoptotic effect of HSP90 inhibition. Together, our results demonstrate that HSP90 inhibition impairs BL cell survival by interfering with tonic BCR signaling, thus providing a molecular rationale for the use of HSP90 inhibitors in the treatment of BL. | ||
| 700 | 1 | |a Tomska, Katarzyna |e VerfasserIn |0 (DE-588)1171347154 |0 (DE-627)1040490670 |0 (DE-576)513697314 |4 aut | |
| 700 | 1 | |a Zenz, Thorsten |d 1970- |e VerfasserIn |0 (DE-588)114963738 |0 (DE-627)577184202 |0 (DE-576)180278266 |4 aut | |
| 700 | 1 | |a Oellerich, Thomas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 129(2017), 5, Seite 598-608 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling |
| 773 | 1 | 8 | |g volume:129 |g year:2017 |g number:5 |g pages:598-608 |g extent:11 |a HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1182/blood-2016-06-721423 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.bloodjournal.org/content/129/5/598 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181114 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 114963738 |a Zenz, Thorsten |m 114963738:Zenz, Thorsten |p 16 | ||
| 998 | |g 1171347154 |a Tomska, Katarzyna |m 1171347154:Tomska, Katarzyna |d 910000 |d 910500 |e 910000PT1171347154 |e 910500PT1171347154 |k 0/910000/ |k 1/910000/910500/ |p 5 | ||
| 999 | |a KXP-PPN1583697888 |e 3032283418 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling","title_sort":"HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling"}],"person":[{"roleDisplay":"VerfasserIn","display":"Walter, Roland","role":"aut","family":"Walter","given":"Roland"},{"given":"Katarzyna","family":"Tomska","role":"aut","display":"Tomska, Katarzyna","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zenz, Thorsten","given":"Thorsten","family":"Zenz"},{"family":"Oellerich","given":"Thomas","roleDisplay":"VerfasserIn","display":"Oellerich, Thomas","role":"aut"}],"recId":"1583697888","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["First edition: November 15, 2016","Gesehen am 14.11.2018"],"id":{"eki":["1583697888"],"doi":["10.1182/blood-2016-06-721423"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"February 2, 2017"}],"name":{"displayForm":["Roland Walter, Kuan-Ting Pan, Carmen Doebele, Federico Comoglio, Katarzyna Tomska, Hanibal Bohnenberger, Ryan M. Young, Laura Jacobs, Ulrich Keller, Halvard Bönig, Michael Engelke, Andreas Rosenwald, Henning Urlaub, Louis M. Staudt, Hubert Serve, Thorsten Zenz, Thomas Oellerich"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1528-0020"],"zdb":["1468538-3"],"eki":["266886647"]},"origin":[{"publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946","dateIssuedDisp":"1946-","publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif."}],"recId":"266886647","corporate":[{"display":"American Society of Hematology","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"note":["Gesehen am 21.04.2023"],"disp":"HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signalingBlood","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Blood online"}],"part":{"extent":"11","volume":"129","text":"129(2017), 5, Seite 598-608","issue":"5","pages":"598-608","year":"2017"},"pubHistory":["1.1946 -"],"title":[{"title":"Blood","subtitle":"journal of the American Society of Hematology","title_sort":"Blood"}]}],"physDesc":[{"extent":"11 S."}]} | ||
| SRT | |a WALTERROLAHSP90PROMO2201 | ||