Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells
BACKGROUND: Primary cutaneous B-cell lymphomas (PCBCL) are subdivided into the aggressive form, primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL, LT) and two subtypes of indolent behaviour (primary cutaneous follicle centre lymphoma and primary cutaneous marginal zone B-cell lymphom...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 April 2012
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| In: |
British journal of dermatology
Year: 2012, Jahrgang: 167, Heft: 2, Pages: 348-358 |
| ISSN: | 1365-2133 |
| DOI: | 10.1111/j.1365-2133.2012.10987.x |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1111/j.1365-2133.2012.10987.x
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| Verfasserangaben: | M. Felcht, M. Heck, C. Weiss, J.C. Becker, E. Dippel, C.S.L. Müller, D. Nashan, M.M. Sachse, J.P. Nicolay, N. Booken, S. Goerdt, and C.-D. Klemke |
MARC
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| 245 | 1 | 0 | |a Expression of the T-cell regulatory marker FOXP3 in primary cutaneous large B-cell lymphoma tumour cells |c M. Felcht, M. Heck, C. Weiss, J.C. Becker, E. Dippel, C.S.L. Müller, D. Nashan, M.M. Sachse, J.P. Nicolay, N. Booken, S. Goerdt, and C.-D. Klemke |
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| 520 | |a BACKGROUND: Primary cutaneous B-cell lymphomas (PCBCL) are subdivided into the aggressive form, primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL, LT) and two subtypes of indolent behaviour (primary cutaneous follicle centre lymphoma and primary cutaneous marginal zone B-cell lymphoma). The difference in clinical behaviour can be explained by the tumour cell itself, or the lymphoma microenvironment including the antitumour immune response. OBJECTIVES: To investigate the presence of regulatory T cells (Treg), CD4+CD25+FOXP3+, in the microenvironment of PCBCL in correlation with clinical outcome. METHODS: Tumour specimens of 55 consecutive cases of PCBCL were blinded and analysed for FOXP3, CD4 and CD25 expression by immunohistochemistry. Confocal images were taken with a Leica SP5. Statistical analyses were performed to determine significance. The test was considered significant when P<0.05. RESULTS: The CD4 and FOXP3 expression as well as the CD4/FOXP3 ratio were significantly increased in PCBCL of indolent behaviour in contrast to PCLBCL, LT (P=0.0002 for CD4, P<0.0001 for FOXP3 and P=0.0345 for FOXP3/CD4 ratio). CD25 expression did not differ in the three groups (P=0.9414). Within the group of patients with PCLBCL, LT we identified a subgroup with FOXP3+ tumour cells as demonstrated by CD20/FOXP3 double stainings. Patients with FOXP3+ PCLBCL, LT tumour cells showed a better prognosis on Kaplan-Meier analysis. CONCLUSION: High numbers of Treg in the lymphoma microenvironment correlate with a better prognosis in PCBCL. In PCLBCL, LT the presence of FOXP3+ tumour cells is beneficial for prognosis suggesting that FOXP3 expression of PCLBCL, LT tumour cells might serve as a tumour suppressor. | ||
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Biomarkers, Tumor | |
| 650 | 4 | |a CD4 Antigens | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Forkhead Transcription Factors | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Interleukin-2 Receptor alpha Subunit | |
| 650 | 4 | |a Kaplan-Meier Estimate | |
| 650 | 4 | |a Lymphoma, B-Cell, Marginal Zone | |
| 650 | 4 | |a Lymphoma, Large B-Cell, Diffuse | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Skin Neoplasms | |
| 650 | 4 | |a Tumor Microenvironment | |
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