Topography of cancer-associated immune cells in human solid tumors
Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across v...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 September 2018
|
| In: |
eLife
Year: 2018, Jahrgang: 7 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.36967 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.7554/eLife.36967 Verlag, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133554/ 
|
| Verfasserangaben: | Jakob Nikolas Kather, Meggy Suarez-Carmona, Pornpimol Charoentong, Cleo-Aron Weis, Daniela Hirsch, Peter Bankhead, Marcel Horning, Dyke Ferber, Ivan Kel, Esther Herpel, Sarah Schott, Inka Zörnig, Jochen Utikal, Alexander Marx, Timo Gaiser, Herrmann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Dirk Jäger, Niels Halama |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1583743685 | ||
| 003 | DE-627 | ||
| 005 | 20230427161316.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181115s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.36967 |2 doi | |
| 035 | |a (DE-627)1583743685 | ||
| 035 | |a (DE-576)513743685 | ||
| 035 | |a (DE-599)BSZ513743685 | ||
| 035 | |a (OCoLC)1341022720 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kather, Jakob Nikolas |d 1989- |e VerfasserIn |0 (DE-588)1064064914 |0 (DE-627)812897587 |0 (DE-576)423589091 |4 aut | |
| 245 | 1 | 0 | |a Topography of cancer-associated immune cells in human solid tumors |c Jakob Nikolas Kather, Meggy Suarez-Carmona, Pornpimol Charoentong, Cleo-Aron Weis, Daniela Hirsch, Peter Bankhead, Marcel Horning, Dyke Ferber, Ivan Kel, Esther Herpel, Sarah Schott, Inka Zörnig, Jochen Utikal, Alexander Marx, Timo Gaiser, Herrmann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Dirk Jäger, Niels Halama |
| 264 | 1 | |c 04 September 2018 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.11.2018 | ||
| 520 | |a Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (‘hot’), non-inflamed (‘cold’) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors. | ||
| 700 | 1 | |a Suarez-Carmona, Meggy |e VerfasserIn |0 (DE-588)1099728061 |0 (DE-627)858742993 |0 (DE-576)469344083 |4 aut | |
| 700 | 1 | |a Charoentong, Pornpimol |e VerfasserIn |0 (DE-588)1148968687 |0 (DE-627)1009228668 |0 (DE-576)496484850 |4 aut | |
| 700 | 1 | |a Weis, Cleo-Aron Thias |d 1985- |e VerfasserIn |0 (DE-588)1062803752 |0 (DE-627)806961198 |0 (DE-576)42022730X |4 aut | |
| 700 | 1 | |a Hirsch, Daniela |d 1987- |e VerfasserIn |0 (DE-588)1070596620 |0 (DE-627)824096347 |0 (DE-576)431928525 |4 aut | |
| 700 | 1 | |a Ferber, Dyke |e VerfasserIn |0 (DE-588)1171467079 |0 (DE-627)1040545629 |0 (DE-576)513746056 |4 aut | |
| 700 | 1 | |a Kel, Ivan |d 1986- |e VerfasserIn |0 (DE-588)117147198X |0 (DE-627)1040547893 |0 (DE-576)513747613 |4 aut | |
| 700 | 1 | |a Herpel, Esther |d 1973- |e VerfasserIn |0 (DE-588)12965227X |0 (DE-627)476593662 |0 (DE-576)297767984 |4 aut | |
| 700 | 1 | |a Schott, Sarah |d 1981- |e VerfasserIn |0 (DE-588)133730816 |0 (DE-627)552697281 |0 (DE-576)27460678X |4 aut | |
| 700 | 1 | |a Zörnig, Inka |e VerfasserIn |0 (DE-588)1022346741 |0 (DE-627)716954850 |0 (DE-576)36517937X |4 aut | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 700 | 1 | |a Marx, Alexander |d 1956- |e VerfasserIn |0 (DE-588)122478258 |0 (DE-627)705923673 |0 (DE-576)214254488 |4 aut | |
| 700 | 1 | |a Gaiser, Timo |d 1975- |e VerfasserIn |0 (DE-588)1030402280 |0 (DE-627)735221685 |0 (DE-576)378226533 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Chang-Claude, Jenny |e VerfasserIn |0 (DE-588)1049304993 |0 (DE-627)781626188 |0 (DE-576)168344475 |4 aut | |
| 700 | 1 | |a Hoffmeister, Michael |d 1973- |e VerfasserIn |0 (DE-588)134103726 |0 (DE-627)560880820 |0 (DE-576)277089565 |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Halama, Niels |d 1977- |e VerfasserIn |0 (DE-588)13087325X |0 (DE-627)507228723 |0 (DE-576)251045706 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 7(2018), Artikel-ID e36967 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Topography of cancer-associated immune cells in human solid tumors |
| 773 | 1 | 8 | |g volume:7 |g year:2018 |g elocationid:e36967 |g extent:19 |a Topography of cancer-associated immune cells in human solid tumors |
| 856 | 4 | 0 | |u http://dx.doi.org/10.7554/eLife.36967 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133554/ |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181115 | ||
| 992 | |a 20181115 | ||
| 993 | |a Article | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 994 | |a 2018 | ||
| 998 | |g 13087325X |a Halama, Niels |m 13087325X:Halama, Niels |d 910000 |d 910100 |e 910000PH13087325X |e 910100PH13087325X |k 0/910000/ |k 1/910000/910100/ |p 20 |y j | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 19 | ||
| 998 | |g 134103726 |a Hoffmeister, Michael |m 134103726:Hoffmeister, Michael |d 50000 |e 50000PH134103726 |k 0/50000/ |p 18 | ||
| 998 | |g 1049304993 |a Chang-Claude, Jenny |m 1049304993:Chang-Claude, Jenny |d 50000 |e 50000PC1049304993 |k 0/50000/ |p 17 | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 16 | ||
| 998 | |g 1030402280 |a Gaiser, Timo |m 1030402280:Gaiser, Timo |d 60000 |d 63400 |e 60000PG1030402280 |e 63400PG1030402280 |k 0/60000/ |k 1/60000/63400/ |p 15 | ||
| 998 | |g 122478258 |a Marx, Alexander |m 122478258:Marx, Alexander |d 60000 |d 63400 |e 60000PM122478258 |e 63400PM122478258 |k 0/60000/ |k 1/60000/63400/ |p 14 | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ |p 13 | ||
| 998 | |g 1022346741 |a Zörnig, Inka |m 1022346741:Zörnig, Inka |d 910000 |d 910100 |e 910000PZ1022346741 |e 910100PZ1022346741 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 133730816 |a Schott, Sarah |m 133730816:Schott, Sarah |d 910000 |d 910400 |e 910000PS133730816 |e 910400PS133730816 |k 0/910000/ |k 1/910000/910400/ |p 11 | ||
| 998 | |g 12965227X |a Herpel, Esther |m 12965227X:Herpel, Esther |d 910000 |d 912000 |e 910000PH12965227X |e 912000PH12965227X |k 0/910000/ |k 1/910000/912000/ |p 10 | ||
| 998 | |g 117147198X |a Kel, Ivan |m 117147198X:Kel, Ivan |d 50000 |e 50000PK117147198X |k 0/50000/ |p 9 | ||
| 998 | |g 1171467079 |a Ferber, Dyke |m 1171467079:Ferber, Dyke |d 910000 |e 910000PF1171467079 |k 0/910000/ |p 8 | ||
| 998 | |g 1070596620 |a Hirsch, Daniela |m 1070596620:Hirsch, Daniela |d 60000 |d 63400 |e 60000PH1070596620 |e 63400PH1070596620 |k 0/60000/ |k 1/60000/63400/ |p 5 | ||
| 998 | |g 1062803752 |a Weis, Cleo-Aron Thias |m 1062803752:Weis, Cleo-Aron Thias |d 60000 |d 63400 |e 60000PW1062803752 |e 63400PW1062803752 |k 0/60000/ |k 1/60000/63400/ |p 4 | ||
| 998 | |g 1148968687 |a Charoentong, Pornpimol |m 1148968687:Charoentong, Pornpimol |d 910000 |d 910100 |e 910000PC1148968687 |e 910100PC1148968687 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1099728061 |a Suarez-Carmona, Meggy |m 1099728061:Suarez-Carmona, Meggy |d 910000 |d 910100 |e 910000PS1099728061 |e 910100PS1099728061 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1064064914 |a Kather, Jakob Nikolas |m 1064064914:Kather, Jakob Nikolas |d 50000 |e 50000PK1064064914 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1583743685 |e 303243193X | ||
| 999 | |a KXP-PPN1583743685 |e 3032423228 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.7554/eLife.36967"],"eki":["1583743685"]},"name":{"displayForm":["Jakob Nikolas Kather, Meggy Suarez-Carmona, Pornpimol Charoentong, Cleo-Aron Weis, Daniela Hirsch, Peter Bankhead, Marcel Horning, Dyke Ferber, Ivan Kel, Esther Herpel, Sarah Schott, Inka Zörnig, Jochen Utikal, Alexander Marx, Timo Gaiser, Herrmann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Dirk Jäger, Niels Halama"]},"note":["Gesehen am 15.11.2018"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Topography of cancer-associated immune cells in human solid tumors","title_sort":"Topography of cancer-associated immune cells in human solid tumors"}],"person":[{"display":"Kather, Jakob Nikolas","given":"Jakob Nikolas","role":"aut","family":"Kather"},{"display":"Suarez-Carmona, Meggy","family":"Suarez-Carmona","role":"aut","given":"Meggy"},{"family":"Charoentong","given":"Pornpimol","role":"aut","display":"Charoentong, Pornpimol"},{"display":"Weis, Cleo-Aron Thias","given":"Cleo-Aron Thias","role":"aut","family":"Weis"},{"display":"Hirsch, Daniela","family":"Hirsch","given":"Daniela","role":"aut"},{"family":"Ferber","role":"aut","given":"Dyke","display":"Ferber, Dyke"},{"family":"Kel","role":"aut","given":"Ivan","display":"Kel, Ivan"},{"display":"Herpel, Esther","family":"Herpel","role":"aut","given":"Esther"},{"display":"Schott, Sarah","role":"aut","given":"Sarah","family":"Schott"},{"role":"aut","given":"Inka","family":"Zörnig","display":"Zörnig, Inka"},{"display":"Utikal, Jochen","family":"Utikal","role":"aut","given":"Jochen"},{"given":"Alexander","role":"aut","family":"Marx","display":"Marx, Alexander"},{"display":"Gaiser, Timo","family":"Gaiser","given":"Timo","role":"aut"},{"family":"Brenner","role":"aut","given":"Hermann","display":"Brenner, Hermann"},{"display":"Chang-Claude, Jenny","family":"Chang-Claude","given":"Jenny","role":"aut"},{"family":"Hoffmeister","role":"aut","given":"Michael","display":"Hoffmeister, Michael"},{"display":"Jäger, Dirk","family":"Jäger","given":"Dirk","role":"aut"},{"display":"Halama, Niels","family":"Halama","role":"aut","given":"Niels"}],"relHost":[{"disp":"Topography of cancer-associated immune cells in human solid tumorseLife","physDesc":[{"extent":"Online-Ressource"}],"recId":"728518384","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.06.17"],"title":[{"title_sort":"eLife","title":"eLife"}],"origin":[{"dateIssuedDisp":"2012-","dateIssuedKey":"2012","publisherPlace":"Cambridge","publisher":"eLife Sciences Publications"}],"id":{"issn":["2050-084X"],"eki":["728518384"],"zdb":["2687154-3"]},"part":{"year":"2018","text":"7(2018), Artikel-ID e36967","volume":"7","extent":"19"},"pubHistory":["1.2012 -"],"titleAlt":[{"title":"eLife journal"}]}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"04 September 2018"}],"physDesc":[{"extent":"19 S."}],"recId":"1583743685"} | ||
| SRT | |a KATHERJAKOTOPOGRAPHY0420 | ||