AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model
Aims: G protein-coupled receptor kinase 2 (GRK2), which is markedly upregulated in failing human myocardium, has been implicated as a contributing factor or consequence of heart failure (HF). Importantly, cardiac-specific GRK2 knockout mice have recently proved the pathological nature of GRK2 in HF....
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
European heart journal
Year: 2013, Jahrgang: 34, Heft: 19, Pages: 1437-1447 |
| ISSN: | 1522-9645 |
| DOI: | 10.1093/eurheartj/ehr447 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1093/eurheartj/ehr447 Verlag, Volltext: https://academic.oup.com/eurheartj/article/34/19/1437/422831 
|
| Verfasserangaben: | Philip W.J. Raake, Philipp Schlegel, Jan Ksienzyk, Julia Reinkober, Jens Barthelmes, Stefanie Schinkel, Sven Pleger, Walter Mier, Uwe Haberkorn, Walter J. Koch, Hugo A. Katus, Patrick Most, and Oliver J. Müller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1583842489 | ||
| 003 | DE-627 | ||
| 005 | 20220815060620.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181119s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/eurheartj/ehr447 |2 doi | |
| 035 | |a (DE-627)1583842489 | ||
| 035 | |a (DE-576)513842489 | ||
| 035 | |a (DE-599)BSZ513842489 | ||
| 035 | |a (OCoLC)1341023829 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Raake, Philip |d 1975- |e VerfasserIn |0 (DE-588)129151246 |0 (DE-627)390021725 |0 (DE-576)297510568 |4 aut | |
| 245 | 1 | 0 | |a AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model |c Philip W.J. Raake, Philipp Schlegel, Jan Ksienzyk, Julia Reinkober, Jens Barthelmes, Stefanie Schinkel, Sven Pleger, Walter Mier, Uwe Haberkorn, Walter J. Koch, Hugo A. Katus, Patrick Most, and Oliver J. Müller |
| 246 | 3 | 0 | |a Beta |
| 246 | 3 | 3 | |a AAV6.betaARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model |
| 264 | 1 | |c 2013 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online publish-ahead-of-print 19 January 2012 | ||
| 500 | |a Gesehen am 19.11.2018 | ||
| 520 | |a Aims: G protein-coupled receptor kinase 2 (GRK2), which is markedly upregulated in failing human myocardium, has been implicated as a contributing factor or consequence of heart failure (HF). Importantly, cardiac-specific GRK2 knockout mice have recently proved the pathological nature of GRK2 in HF. Targeted inhibition of GRK2 is possible using a peptide inhibitor known as the βARKct, which has rescued several disparate small animal HF models. This study was designed to evaluate long-term βARKct expression in a clinically relevant large animal HF model, using stable myocardial gene delivery with adeno-associated virus serotype 6 (AAV6). | ||
| 700 | 1 | |a Schlegel, Philipp |d 1984- |e VerfasserIn |0 (DE-588)1043833781 |0 (DE-627)77097550X |0 (DE-576)395950260 |4 aut | |
| 700 | 1 | |a Reinkober, Julia |e VerfasserIn |0 (DE-588)104503195X |0 (DE-627)77353251X |0 (DE-576)398342407 |4 aut | |
| 700 | 1 | |a Barthelmes, Jens |e VerfasserIn |0 (DE-588)1171759355 |0 (DE-627)1040699855 |0 (DE-576)513843639 |4 aut | |
| 700 | 1 | |a Schinkel, Stefanie |e VerfasserIn |0 (DE-588)141995491 |0 (DE-627)632861630 |0 (DE-576)32727042X |4 aut | |
| 700 | 1 | |a Pleger, Sven Torsten |d 1973- |e VerfasserIn |0 (DE-588)129962473 |0 (DE-627)484985221 |0 (DE-576)297924001 |4 aut | |
| 700 | 1 | |a Mier, Walter |d 1966- |e VerfasserIn |0 (DE-588)12029026X |0 (DE-627)69653567X |0 (DE-576)292141599 |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Most, Patrick |d 1969- |e VerfasserIn |0 (DE-588)124606431 |0 (DE-627)363440267 |0 (DE-576)29440919X |4 aut | |
| 700 | 1 | |a Müller, Oliver J. |d 1971- |e VerfasserIn |0 (DE-588)121693449 |0 (DE-627)705619621 |0 (DE-576)292833504 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European heart journal |d Oxford : Oxford University Press, 1980 |g 34(2013), 19, Seite 1437-1447 |h Online-Ressource |w (DE-627)320415813 |w (DE-600)2001908-7 |w (DE-576)103746846 |x 1522-9645 |7 nnas |a AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model |
| 773 | 1 | 8 | |g volume:34 |g year:2013 |g number:19 |g pages:1437-1447 |g extent:11 |a AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/eurheartj/ehr447 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://academic.oup.com/eurheartj/article/34/19/1437/422831 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181119 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 121693449 |a Müller, Oliver J. |m 121693449:Müller, Oliver J. |d 910000 |d 910100 |d 50000 |e 910000PM121693449 |e 910100PM121693449 |e 50000PM121693449 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 13 |y j | ||
| 998 | |g 124606431 |a Most, Patrick |m 124606431:Most, Patrick |d 910000 |d 910100 |e 910000PM124606431 |e 910100PM124606431 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |e 910000PK108916618 |e 910100PK108916618 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 12029026X |a Mier, Walter |m 12029026X:Mier, Walter |d 910000 |d 911400 |e 910000PM12029026X |e 911400PM12029026X |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 129962473 |a Pleger, Sven Torsten |m 129962473:Pleger, Sven Torsten |d 910000 |d 910100 |e 910000PP129962473 |e 910100PP129962473 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 141995491 |a Schinkel, Stefanie |m 141995491:Schinkel, Stefanie |p 6 | ||
| 998 | |g 1171759355 |a Barthelmes, Jens |m 1171759355:Barthelmes, Jens |d 910000 |d 910100 |e 910000PB1171759355 |e 910100PB1171759355 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 104503195X |a Reinkober, Julia |m 104503195X:Reinkober, Julia |d 910000 |d 910100 |e 910000PR104503195X |e 910100PR104503195X |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1043833781 |a Schlegel, Philipp |m 1043833781:Schlegel, Philipp |d 910000 |d 910100 |e 910000PS1043833781 |e 910100PS1043833781 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 129151246 |a Raake, Philip |m 129151246:Raake, Philip |d 910000 |d 910100 |e 910000PR129151246 |e 910100PR129151246 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1583842489 |e 3032693098 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"titleAlt":[{"title":"AAV6.betaARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Online publish-ahead-of-print 19 January 2012","Gesehen am 19.11.2018"],"language":["eng"],"relHost":[{"recId":"320415813","id":{"eki":["320415813"],"issn":["1522-9645"],"zdb":["2001908-7"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"European heart journal","title_sort":"European heart journal"}],"origin":[{"publisher":"Oxford University Press ; Harcourt","dateIssuedDisp":"1980-","dateIssuedKey":"1980","publisherPlace":"Oxford ; London [u.a.]"}],"part":{"year":"2013","volume":"34","pages":"1437-1447","extent":"11","issue":"19","text":"34(2013), 19, Seite 1437-1447"},"language":["eng"],"pubHistory":["1.1980 -"],"note":["Gesehen am 12.09.2017"],"disp":"AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure modelEuropean heart journal","type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"title":[{"title":"AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model","title_sort":"AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model"}],"id":{"eki":["1583842489"],"doi":["10.1093/eurheartj/ehr447"]},"physDesc":[{"extent":"11 S."}],"person":[{"display":"Raake, Philip","given":"Philip","role":"aut","family":"Raake"},{"display":"Schlegel, Philipp","given":"Philipp","role":"aut","family":"Schlegel"},{"role":"aut","family":"Reinkober","given":"Julia","display":"Reinkober, Julia"},{"given":"Jens","display":"Barthelmes, Jens","family":"Barthelmes","role":"aut"},{"given":"Stefanie","display":"Schinkel, Stefanie","role":"aut","family":"Schinkel"},{"family":"Pleger","role":"aut","given":"Sven Torsten","display":"Pleger, Sven Torsten"},{"given":"Walter","display":"Mier, Walter","family":"Mier","role":"aut"},{"display":"Haberkorn, Uwe","given":"Uwe","family":"Haberkorn","role":"aut"},{"display":"Katus, Hugo","given":"Hugo","family":"Katus","role":"aut"},{"role":"aut","family":"Most","display":"Most, Patrick","given":"Patrick"},{"family":"Müller","role":"aut","given":"Oliver J.","display":"Müller, Oliver J."}],"recId":"1583842489","name":{"displayForm":["Philip W.J. Raake, Philipp Schlegel, Jan Ksienzyk, Julia Reinkober, Jens Barthelmes, Stefanie Schinkel, Sven Pleger, Walter Mier, Uwe Haberkorn, Walter J. Koch, Hugo A. Katus, Patrick Most, and Oliver J. Müller"]}} | ||
| SRT | |a RAAKEPHILIAAV6ARKCTC2013 | ||