Renal phenotype of young and old telomerase-deficient mice
Telomere shortening in the kidney explains the impaired regenerative capacity, but may not drive the ageing phenotype itself. We investigated kidneys from young and old Terc+/+ and Terc−/− mice of early (G1) and late (G4, G5) generations. Functional parameters declined and age-related morphological...
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| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2015
|
| In: |
Mechanisms of ageing and development
Year: 2015, Volume: 150, Pages: 65-73 |
| ISSN: | 1872-6216 |
| DOI: | 10.1016/j.mad.2015.08.004 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.mad.2015.08.004 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0047637415300087 |
| Author Notes: | Carolin Schildhorn, Christoph Jacobi, Andrea Weißbrodt, Christine Hermstedt, Jens Hendrik Westhoff, Meike Hömme, Raj Bhayadia, Norbert Gretz, Christine Susanne Falk, Roland Schmitt, Verena Bröcker, Bettina Kränzlin, Anette Melk |
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