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Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons

Constitutive activation of the MTOR pathway is a key feature of defects in the tuberous sclerosis complex and other genetic neurodevelopmental diseases, collectively referred to as MTORopathies. MTORC1 hyperactivity promotes anabolic cell functions such as protein synthesis, yet at the same time cat...

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Main Authors: Ebrahimi-Fakhari, Darius (Author) , Saffari, Afshin (Author) , Wahlster, Lara (Author)
Format: Article (Journal)
Language:English
Published: 17 Feb 2017
In: Autophagy
Year: 2017, Volume: 13, Issue: 4, Pages: 754-756
ISSN:1554-8635
DOI:10.1080/15548627.2016.1277310
Online Access:Verlag, Volltext: http://dx.doi.org/10.1080/15548627.2016.1277310
Verlag, Volltext: https://doi.org/10.1080/15548627.2016.1277310
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Author Notes:Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Mustafa Sahin

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