Iron induces anti-tumor activity in tumor-associated macrophages
Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment. Here we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the tumor microenvironment. The occurrence of iron-loaded TAMs...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
08 November 2017
|
| In: |
Frontiers in immunology
Year: 2017, Volume: 8 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2017.01479 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3389/fimmu.2017.01479 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2017.01479/full 
|
| Author Notes: | Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka and Martina U. Muckenthaler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1583932003 | ||
| 003 | DE-627 | ||
| 005 | 20220815062624.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181121s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fimmu.2017.01479 |2 doi | |
| 035 | |a (DE-627)1583932003 | ||
| 035 | |a (DE-576)513932003 | ||
| 035 | |a (DE-599)BSZ513932003 | ||
| 035 | |a (OCoLC)1341024030 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Costa da Silva, Milene |e VerfasserIn |0 (DE-588)116005231X |0 (DE-627)1023148838 |0 (DE-576)505468735 |4 aut | |
| 245 | 1 | 0 | |a Iron induces anti-tumor activity in tumor-associated macrophages |c Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka and Martina U. Muckenthaler |
| 264 | 1 | |c 08 November 2017 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.11.2018 | ||
| 520 | |a Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment. Here we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the tumor microenvironment. The occurrence of iron-loaded TAMs (iTAMs) correlated with reduced tumor size in patients with non-small cell lung cancer. Ex vivo experiments established that TAMs exposed to hemolytic red blood cells were converted into pro-inflammatory macrophages capable of directly killing tumor cells. This anti-tumor effect could also be elicited via iron oxide nanoparticles. When tested in vivo, tumors injected with such iron oxide nanoparticles led to significantly smaller tumor sizes compared to controls. These results identify hemolytic red blood cells and iron as novel players in the tumor microenvironment that repolarize TAMs to exert direct anti-tumor effector function. Thus, the delivery of iron to TAMs emerges as a simple adjuvant therapeutic strategy to promote anti-cancer immune responses. | ||
| 650 | 4 | |a anti-tumor activity | |
| 650 | 4 | |a Heme | |
| 650 | 4 | |a hemolytic red blood cells | |
| 650 | 4 | |a Iron | |
| 650 | 4 | |a iron Nanoparticles | |
| 650 | 4 | |a Macrophage polarization | |
| 650 | 4 | |a Non-small cell lung cancer | |
| 650 | 4 | |a Tumor-associated macrophages | |
| 700 | 1 | |a Breckwoldt, Michael O. |d 1983- |e VerfasserIn |0 (DE-588)1022496298 |0 (DE-627)716993392 |0 (DE-576)365498297 |4 aut | |
| 700 | 1 | |a Vinchi, Francesca |e VerfasserIn |0 (DE-588)1160054029 |0 (DE-627)1023152444 |0 (DE-576)505471280 |4 aut | |
| 700 | 1 | |a Thielmann, Carl Maximilian |d 1991- |e VerfasserIn |0 (DE-588)1160054266 |0 (DE-627)1023153114 |0 (DE-576)505472368 |4 aut | |
| 700 | 1 | |a Meister, Michael |e VerfasserIn |0 (DE-588)1078792046 |0 (DE-627)839461402 |0 (DE-576)451890108 |4 aut | |
| 700 | 1 | |a Muley, Thomas |e VerfasserIn |0 (DE-588)1056885432 |0 (DE-627)794179169 |0 (DE-576)16759284X |4 aut | |
| 700 | 1 | |a Warth, Arne |d 1979- |e VerfasserIn |0 (DE-588)132646145 |0 (DE-627)524716927 |0 (DE-576)260019755 |4 aut | |
| 700 | 1 | |a Platten, Michael |d 1971- |e VerfasserIn |0 (DE-588)121627780 |0 (DE-627)081431848 |0 (DE-576)261969811 |4 aut | |
| 700 | 1 | |a Hentze, Matthias W. |d 1960- |e VerfasserIn |0 (DE-588)143450395 |0 (DE-627)646106775 |0 (DE-576)337135754 |4 aut | |
| 700 | 1 | |a Muckenthaler, Martina |e VerfasserIn |0 (DE-588)1046124595 |0 (DE-627)775766496 |0 (DE-576)173146813 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in immunology |d Lausanne : Frontiers Media, 2010 |g 8(2017), Artikel-ID 1479 |h Online-Ressource |w (DE-627)657998354 |w (DE-600)2606827-8 |w (DE-576)343624834 |x 1664-3224 |7 nnas |a Iron induces anti-tumor activity in tumor-associated macrophages |
| 773 | 1 | 8 | |g volume:8 |g year:2017 |g elocationid:1479 |g extent:14 |a Iron induces anti-tumor activity in tumor-associated macrophages |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fimmu.2017.01479 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fimmu.2017.01479/full |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181121 | ||
| 993 | |a Article | ||
| 994 | |a 2017 | ||
| 998 | |g 1046124595 |a Muckenthaler, Martina |m 1046124595:Muckenthaler, Martina |d 910000 |d 910500 |d 700000 |d 718000 |e 910000PM1046124595 |e 910500PM1046124595 |e 700000PM1046124595 |e 718000PM1046124595 |k 0/910000/ |k 1/910000/910500/ |k 0/700000/ |k 1/700000/718000/ |p 33 | ||
| 998 | |g 143450395 |a Hentze, Matthias W. |m 143450395:Hentze, Matthias W. |d 50000 |e 50000PH143450395 |k 0/50000/ |p 11 | ||
| 998 | |g 121627780 |a Platten, Michael |m 121627780:Platten, Michael |d 60000 |d 62700 |e 60000PP121627780 |e 62700PP121627780 |k 0/60000/ |k 1/60000/62700/ |p 10 | ||
| 998 | |g 132646145 |a Warth, Arne |m 132646145:Warth, Arne |d 910000 |d 912000 |e 910000PW132646145 |e 912000PW132646145 |k 0/910000/ |k 1/910000/912000/ |p 9 | ||
| 998 | |g 1056885432 |a Muley, Thomas |m 1056885432:Muley, Thomas |d 910000 |d 950000 |d 950900 |e 910000PM1056885432 |e 950000PM1056885432 |e 950900PM1056885432 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 8 | ||
| 998 | |g 1078792046 |a Meister, Michael |m 1078792046:Meister, Michael |d 910000 |d 950000 |d 950900 |e 910000PM1078792046 |e 950000PM1078792046 |e 950900PM1078792046 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |p 7 | ||
| 998 | |g 1160054266 |a Thielmann, Carl Maximilian |m 1160054266:Thielmann, Carl Maximilian |d 50000 |e 50000PT1160054266 |k 0/50000/ |p 6 | ||
| 998 | |g 1160054029 |a Vinchi, Francesca |m 1160054029:Vinchi, Francesca |p 3 | ||
| 998 | |g 1022496298 |a Breckwoldt, Michael O. |m 1022496298:Breckwoldt, Michael O. |d 910000 |d 911100 |e 910000PB1022496298 |e 911100PB1022496298 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 116005231X |a Costa da Silva, Milene |m 116005231X:Costa da Silva, Milene |d 910000 |d 910500 |e 910000PC116005231X |e 910500PC116005231X |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1583932003 |e 3032868157 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1583932003","name":{"displayForm":["Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka and Martina U. Muckenthaler"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1583932003"],"doi":["10.3389/fimmu.2017.01479"]},"origin":[{"dateIssuedKey":"2017","dateIssuedDisp":"08 November 2017"}],"note":["Gesehen am 21.11.2018"],"physDesc":[{"extent":"14 S."}],"relHost":[{"part":{"text":"8(2017), Artikel-ID 1479","year":"2017","volume":"8","extent":"14"},"title":[{"title":"Frontiers in immunology","title_sort":"Frontiers in immunology"}],"disp":"Iron induces anti-tumor activity in tumor-associated macrophagesFrontiers in immunology","type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"origin":[{"publisherPlace":"Lausanne","dateIssuedKey":"2010","publisher":"Frontiers Media","dateIssuedDisp":"2010-"}],"note":["Gesehen am 07.11.13"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"657998354","id":{"zdb":["2606827-8"],"eki":["657998354"],"issn":["1664-3224"]},"pubHistory":["1.2010 -"]}],"title":[{"title":"Iron induces anti-tumor activity in tumor-associated macrophages","title_sort":"Iron induces anti-tumor activity in tumor-associated macrophages"}],"person":[{"display":"Costa da Silva, Milene","role":"aut","family":"Costa da Silva","given":"Milene"},{"given":"Michael O.","family":"Breckwoldt","role":"aut","display":"Breckwoldt, Michael O."},{"display":"Vinchi, Francesca","role":"aut","family":"Vinchi","given":"Francesca"},{"role":"aut","display":"Thielmann, Carl Maximilian","family":"Thielmann","given":"Carl Maximilian"},{"family":"Meister","given":"Michael","display":"Meister, Michael","role":"aut"},{"role":"aut","display":"Muley, Thomas","given":"Thomas","family":"Muley"},{"family":"Warth","given":"Arne","display":"Warth, Arne","role":"aut"},{"display":"Platten, Michael","role":"aut","family":"Platten","given":"Michael"},{"display":"Hentze, Matthias W.","role":"aut","given":"Matthias W.","family":"Hentze"},{"family":"Muckenthaler","given":"Martina","display":"Muckenthaler, Martina","role":"aut"}]} | ||
| SRT | |a COSTADASILIRONINDUCE0820 | ||