A gene expression signature for high-risk multiple myeloma
There is a strong need to better predict the survival of patients with newly diagnosed multiple myeloma (MM). As gene expression profiles (GEPs) reflect the biology of MM in individual patients, we built a prognostic signature based on GEPs. GEPs obtained from newly diagnosed MM patients included in...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
08 May 2012
|
| In: |
Leukemia
Year: 2012, Jahrgang: 26, Heft: 11, Pages: 2406-2413 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2012.127 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/leu.2012.127 Verlag, Volltext: https://www.nature.com/articles/leu2012127 
|
| Verfasserangaben: | R. Kuiper, A. Broyl, Y. de Knegt, M.H. van Vliet, E.H. van Beers, B. van der Holt, L. el Jarari, G. Mulligan, W. Gregory, G. Morgan, H. Goldschmidt, H.M. Lokhorst, M. van Duin and P. Sonneveld |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1583951563 | ||
| 003 | DE-627 | ||
| 005 | 20220815063026.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181122s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/leu.2012.127 |2 doi | |
| 035 | |a (DE-627)1583951563 | ||
| 035 | |a (DE-576)513951563 | ||
| 035 | |a (DE-599)BSZ513951563 | ||
| 035 | |a (OCoLC)1341023888 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kuiper, Rowan |e VerfasserIn |0 (DE-588)1172028540 |0 (DE-627)1040841686 |0 (DE-576)51395189X |4 aut | |
| 245 | 1 | 2 | |a A gene expression signature for high-risk multiple myeloma |c R. Kuiper, A. Broyl, Y. de Knegt, M.H. van Vliet, E.H. van Beers, B. van der Holt, L. el Jarari, G. Mulligan, W. Gregory, G. Morgan, H. Goldschmidt, H.M. Lokhorst, M. van Duin and P. Sonneveld |
| 264 | 1 | |c 08 May 2012 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.11.2018 | ||
| 520 | |a There is a strong need to better predict the survival of patients with newly diagnosed multiple myeloma (MM). As gene expression profiles (GEPs) reflect the biology of MM in individual patients, we built a prognostic signature based on GEPs. GEPs obtained from newly diagnosed MM patients included in the HOVON65/GMMG-HD4 trial (n=290) were used as training data. Using this set, a prognostic signature of 92 genes (EMC-92-gene signature) was generated by supervised principal component analysis combined with simulated annealing. Performance of the EMC-92-gene signature was confirmed in independent validation sets of newly diagnosed (total therapy (TT)2, n=351; TT3, n=142; MRC-IX, n=247) and relapsed patients (APEX, n=264). In all the sets, patients defined as high-risk by the EMC-92-gene signature show a clearly reduced overall survival (OS) with a hazard ratio (HR) of 3.40 (95% confidence interval (CI): 2.19-5.29) for the TT2 study, 5.23 (95% CI: 2.46-11.13) for the TT3 study, 2.38 (95% CI: 1.65-3.43) for the MRC-IX study and 3.01 (95% CI: 2.06-4.39) for the APEX study (P<0.0001 in all studies). In multivariate analyses this signature was proven to be independent of the currently used prognostic factors. The EMC-92-gene signature is better or comparable to previously published signatures. This signature contributes to risk assessment in clinical trials and could provide a tool for treatment choices in high-risk MM patients. | ||
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 26(2012), 11, Seite 2406-2413 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a A gene expression signature for high-risk multiple myeloma |
| 773 | 1 | 8 | |g volume:26 |g year:2012 |g number:11 |g pages:2406-2413 |g extent:8 |a A gene expression signature for high-risk multiple myeloma |
| 787 | 0 | 8 | |i Errata |a Kuiper, Rowan |t Corrigendum: A gene expression signature for high-risk multiple myeloma |d 2014 |w (DE-627)1786264269 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/leu.2012.127 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/leu2012127 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181122 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |e 910000PG102258023X |e 910100PG102258023X |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 999 | |a KXP-PPN1583951563 |e 3032898218 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1583951563"],"doi":["10.1038/leu.2012.127"]},"recId":"1583951563","relHost":[{"id":{"eki":["32046699X"],"issn":["1476-5551"],"zdb":["2008023-2"]},"recId":"32046699X","physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"A gene expression signature for high-risk multiple myelomaLeukemia","note":["Gesehen am 15.03.04"],"origin":[{"dateIssuedDisp":"1997-","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","dateIssuedKey":"1997","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke"}],"pubHistory":["Nachgewiesen 11.1997 -"],"title":[{"subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title_sort":"Leukemia","title":"Leukemia"}],"part":{"volume":"26","extent":"8","year":"2012","pages":"2406-2413","text":"26(2012), 11, Seite 2406-2413","issue":"11"},"language":["eng"]}],"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["R. Kuiper, A. Broyl, Y. de Knegt, M.H. van Vliet, E.H. van Beers, B. van der Holt, L. el Jarari, G. Mulligan, W. Gregory, G. Morgan, H. Goldschmidt, H.M. Lokhorst, M. van Duin and P. Sonneveld"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"gene expression signature for high-risk multiple myeloma","title":"A gene expression signature for high-risk multiple myeloma"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"08 May 2012"}],"note":["Gesehen am 22.11.2018"],"language":["eng"],"person":[{"display":"Kuiper, Rowan","family":"Kuiper","given":"Rowan","role":"aut"},{"display":"Goldschmidt, Hartmut","family":"Goldschmidt","role":"aut","given":"Hartmut"}]} | ||
| SRT | |a KUIPERROWAGENEEXPRES0820 | ||