MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tis...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2012
|
| In: |
Leukemia research
Year: 2012, Volume: 36, Issue: 9, Pages: 1185-1192 |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2012.05.009 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.leukres.2012.05.009 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0145212612002342 
|
| Author Notes: | Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1584442549 | ||
| 003 | DE-627 | ||
| 005 | 20220815064929.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181126s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.leukres.2012.05.009 |2 doi | |
| 035 | |a (DE-627)1584442549 | ||
| 035 | |a (DE-576)514442549 | ||
| 035 | |a (DE-599)BSZ514442549 | ||
| 035 | |a (OCoLC)1341024395 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wernicke, Caroline |e VerfasserIn |0 (DE-588)1172215715 |0 (DE-627)1040986692 |0 (DE-576)51442334X |4 aut | |
| 245 | 1 | 0 | |a MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival |c Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald |
| 264 | 1 | |c September 2012 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.11.2018 | ||
| 520 | |a Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a comprehensive transcriptome analysis identifying MondoA (MLXIP) - a transcription factor regulating glycolysis - to be overexpressed in ALL compared to normal tissues. Using microarray-profiling, gene-set enrichment analysis, RNA interference and functional assays we show that MondoA overexpression increases glucose catabolism and maintains a more immature phenotype, which is associated with enhanced survival and clonogenicity of leukemia cells. These data point to an important contribution of MondoA to leukemia aggressiveness and make MondoA a potential candidate for targeted treatment of ALL. | ||
| 650 | 4 | |a Clonogenicity | |
| 650 | 4 | |a Differentiation | |
| 650 | 4 | |a Leukemia | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a MondoA | |
| 650 | 4 | |a MondoB | |
| 650 | 4 | |a Survival | |
| 700 | 1 | |a Bandapalli, Obul Reddy |d 1977- |e VerfasserIn |0 (DE-588)13397121X |0 (DE-627)559235070 |0 (DE-576)30022544X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia research |d Amsterdam [u.a.] : Elsevier Science, 1977 |g 36(2012), 9, Seite 1185-1192 |h Online-Ressource |w (DE-627)320467031 |w (DE-600)2008028-1 |w (DE-576)095956301 |x 1873-5835 |7 nnas |a MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival |
| 773 | 1 | 8 | |g volume:36 |g year:2012 |g number:9 |g pages:1185-1192 |g extent:8 |a MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.leukres.2012.05.009 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0145212612002342 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181126 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 13397121X |a Bandapalli, Obul Reddy |m 13397121X:Bandapalli, Obul Reddy |d 910000 |d 910500 |e 910000PB13397121X |e 910500PB13397121X |k 0/910000/ |k 1/910000/910500/ |p 6 | ||
| 999 | |a KXP-PPN1584442549 |e 3034065930 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival","title_sort":"MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival"}],"language":["eng"],"id":{"doi":["10.1016/j.leukres.2012.05.009"],"eki":["1584442549"]},"physDesc":[{"extent":"8 S."}],"relHost":[{"pubHistory":["1.1977 -"],"part":{"volume":"36","text":"36(2012), 9, Seite 1185-1192","year":"2012","extent":"8","pages":"1185-1192","issue":"9"},"language":["eng"],"title":[{"title":"Leukemia research","subtitle":"clinical and laboratory studies","title_sort":"Leukemia research"}],"note":["Gesehen am 16.01.20","Ungezählte Beil.: Supplement"],"id":{"issn":["1873-5835"],"zdb":["2008028-1"],"eki":["320467031"]},"disp":"MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survivalLeukemia research","physDesc":[{"extent":"Online-Ressource"}],"recId":"320467031","origin":[{"dateIssuedKey":"1977","dateIssuedDisp":"1977-","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"note":["Gesehen am 26.11.2018"],"origin":[{"dateIssuedDisp":"September 2012","dateIssuedKey":"2012"}],"recId":"1584442549","type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","given":"Caroline","display":"Wernicke, Caroline","family":"Wernicke"},{"display":"Bandapalli, Obul Reddy","role":"aut","given":"Obul Reddy","family":"Bandapalli"}],"name":{"displayForm":["Caroline M. Wernicke, Günther H.S. Richter, Beate C. Beinvogl, Stephanie Plehm, Anna M. Schlitter, Obul R. Bandapalli, Olivia Prazeres da Costa, Uwe E. Hattenhorst, Ines Volkmer, Martin S. Staege, Irene Esposito, Stefan Burdach, Thomas G.P. Grunewald"]}} | ||
| SRT | |a WERNICKECAMONDOAISHI2012 | ||