Von Willebrand factor and alkaline phosphatase predict re-transplantation-free survival after the first liver transplantation
BackgroundAfter liver transplantation (LT), there are liver-related, infectious and cardiovascular complications that contribute to reduced graft survival. These conditions are associated with an increase in the Von Willebrand factor antigen (VWF-Ag), which was previously correlated with survival in...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2017
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| In: |
United european gastroenterology journal
Year: 2017, Volume: 5, Issue: 1, Pages: 86-93 |
| ISSN: | 2050-6414 |
| DOI: | 10.1177/2050640616650060 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1177/2050640616650060 Verlag, Volltext: https://doi.org/10.1177/2050640616650060 
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| Author Notes: | Andreas Wannhoff, Conrad Rauber, Kilian Friedrich, Christian Rupp, Wolfgang Stremmel, Karl Heinz Weiss, Peter Schemmer, Daniel N Gotthardt |
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| 245 | 1 | 0 | |a Von Willebrand factor and alkaline phosphatase predict re-transplantation-free survival after the first liver transplantation |c Andreas Wannhoff, Conrad Rauber, Kilian Friedrich, Christian Rupp, Wolfgang Stremmel, Karl Heinz Weiss, Peter Schemmer, Daniel N Gotthardt |
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| 520 | |a BackgroundAfter liver transplantation (LT), there are liver-related, infectious and cardiovascular complications that contribute to reduced graft survival. These conditions are associated with an increase in the Von Willebrand factor antigen (VWF-Ag), which was previously correlated with survival in cirrhotic patients.ObjectiveEvaluate VWF-Ag as a predictive marker of re-transplantation-free survival in patients after LT.MethodsWe measured VWF-Ag in patients after first LT and then followed them prospectively with regard to the primary endpoint, namely re-transplantation-free survival.ResultsThere were 6 out of 80 patients who died or received re-LT during follow-up. In these patients, the median VWF-Ag was 510.6%, which was significantly higher (p?=?0.001) than in the patients who were alive at the end of follow-up (with a median VWF-Ag?=?186.8%). At a cut-off of 286.8%, VWF-Ag was significantly correlated with re-transplantation-free survival (p? | ||
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