High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responses

Preliminary evidence suggests that the multikinase inhibitor sorafenib has clinical activity in FLT3-ITD-positive (FLT3-ITD) acute myeloid leukemia (AML). However, the quality and sustainability of achievable remissions and clinical variables that influence the outcome of sorafenib monotherapy are l...

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Bibliographic Details
Main Authors: Metzelder, Stephan (Author) , Kröger, Michael (Author) , Reiter, Andreas (Author) , Dreger, Peter (Author)
Format: Article (Journal)
Language:English
Published: November 2012
In: Leukemia
Year: 2012, Volume: 26, Issue: 11, Pages: 2353-2359
ISSN:1476-5551
DOI:10.1038/leu.2012.105
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/leu.2012.105
Verlag, Volltext: https://www.nature.com/articles/leu2012105
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Author Notes:S. K. Metzelder, T. Schroeder, A. Finck, S. Scholl, M. Fey, K. Götze, Y. C. Linn, M. Kröger, A. Reiter, H. R. Salih, T. Heinicke, R. Stuhlmann, L. Müller, A. Giagounidis, R. G. Meyer, W. Brugger, M. Vöhringer, P. Dreger, M. Mori, N. Basara, K. Schäfer-Eckart, B. Schultheis, C. Baldus, A. Neubauer, A. Burchert