Trial design on prophylaxis and treatment of brain metastases: lessons learned from the EORTC Brain Metastases Strategic Meeting 2012
Brain metastases (BM) occur in a significant proportion of cancer patients and are associated with considerable morbidity and poor prognosis. The trial design in BM patients is particularly challenging, as many disease and patient variables, statistical issues, and the selection of appropriate end-p...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2012
|
| In: |
European journal of cancer
Year: 2012, Jahrgang: 48, Heft: 18, Pages: 3439-3447 |
| ISSN: | 1879-0852 |
| DOI: | 10.1016/j.ejca.2012.07.002 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ejca.2012.07.002 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0959804912005485 
|
| Verfasserangaben: | Matthias Preusser, Frank Winkler, Laurence Collette, Sven Haller, Sandrine Marreaud, Riccardo Soffietti, Martin Klein, Jaap C. Reijneveld, Jörg-Christian Tonn, Brigitta G. Baumert, Paula Mulvenna, Dirk Schadendorf, Renata Duchnowska, Anna Sophie Berghoff, Nancy Lin, David A. Cameron, Yazid Belkacemi, Jacek Jassem, Damien C. Weber |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1584606657 | ||
| 003 | DE-627 | ||
| 005 | 20230427161334.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181128s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejca.2012.07.002 |2 doi | |
| 035 | |a (DE-627)1584606657 | ||
| 035 | |a (DE-576)514606657 | ||
| 035 | |a (DE-599)BSZ514606657 | ||
| 035 | |a (OCoLC)1341024447 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Preusser, Matthias |d 1976- |e VerfasserIn |0 (DE-588)1156333008 |0 (DE-627)1019103949 |0 (DE-576)502110627 |4 aut | |
| 245 | 1 | 0 | |a Trial design on prophylaxis and treatment of brain metastases |b lessons learned from the EORTC Brain Metastases Strategic Meeting 2012 |c Matthias Preusser, Frank Winkler, Laurence Collette, Sven Haller, Sandrine Marreaud, Riccardo Soffietti, Martin Klein, Jaap C. Reijneveld, Jörg-Christian Tonn, Brigitta G. Baumert, Paula Mulvenna, Dirk Schadendorf, Renata Duchnowska, Anna Sophie Berghoff, Nancy Lin, David A. Cameron, Yazid Belkacemi, Jacek Jassem, Damien C. Weber |
| 264 | 1 | |c December 2012 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.11.2018 | ||
| 520 | |a Brain metastases (BM) occur in a significant proportion of cancer patients and are associated with considerable morbidity and poor prognosis. The trial design in BM patients is particularly challenging, as many disease and patient variables, statistical issues, and the selection of appropriate end-points have to be taken into account. During a meeting organised on behalf of the European Organisation for Research and Treatment of Cancer (EORTC), methodological aspects of trial design in BM were discussed. This paper summarises the issues and potential trial strategies discussed during this meeting and may provide some guidance for the design of trials in BM patients. | ||
| 650 | 4 | |a Brain metastases | |
| 650 | 4 | |a Clinical trail | |
| 650 | 4 | |a EORTC | |
| 650 | 4 | |a Prophylaxis | |
| 700 | 1 | |a Winkler, Frank |d 1971- |e VerfasserIn |0 (DE-588)120794586 |0 (DE-627)704993104 |0 (DE-576)292388586 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cancer |d Amsterdam [u.a.] : Elsevier, 1992 |g 48(2012), 18, Seite 3439-3447 |w (DE-627)266883400 |w (DE-600)1468190-0 |w (DE-576)090954173 |x 1879-0852 |7 nnas |a Trial design on prophylaxis and treatment of brain metastases lessons learned from the EORTC Brain Metastases Strategic Meeting 2012 |
| 773 | 1 | 8 | |g volume:48 |g year:2012 |g number:18 |g pages:3439-3447 |g extent:9 |a Trial design on prophylaxis and treatment of brain metastases lessons learned from the EORTC Brain Metastases Strategic Meeting 2012 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ejca.2012.07.002 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0959804912005485 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181128 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 120794586 |a Winkler, Frank |m 120794586:Winkler, Frank |d 910000 |d 911100 |e 910000PW120794586 |e 911100PW120794586 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 999 | |a KXP-PPN1584606657 |e 3035934789 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 28.11.2018"],"relHost":[{"origin":[{"dateIssuedKey":"1992","publisher":"Elsevier ; Pergamon Press","dateIssuedDisp":"1992-","publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]"}],"id":{"eki":["266883400"],"issn":["1879-0852"],"zdb":["1468190-0"]},"part":{"volume":"48","pages":"3439-3447","extent":"9","text":"48(2012), 18, Seite 3439-3447","issue":"18","year":"2012"},"recId":"266883400","disp":"Trial design on prophylaxis and treatment of brain metastases lessons learned from the EORTC Brain Metastases Strategic Meeting 2012European journal of cancer","title":[{"title_sort":"European journal of cancer","title":"European journal of cancer"}],"titleAlt":[{"title":"EJC online"}],"note":["Gesehen am 21.03.24","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"display":"European Organization for Research on Treatment of Cancer","role":"isb"},{"role":"isb","display":"European Association for Cancer Research"},{"role":"isb","display":"European School of Oncology"}],"pubHistory":["28.1992 -"],"language":["eng"]}],"person":[{"family":"Preusser","given":"Matthias","role":"aut","display":"Preusser, Matthias"},{"family":"Winkler","given":"Frank","role":"aut","display":"Winkler, Frank"}],"title":[{"title_sort":"Trial design on prophylaxis and treatment of brain metastases","title":"Trial design on prophylaxis and treatment of brain metastases","subtitle":"lessons learned from the EORTC Brain Metastases Strategic Meeting 2012"}],"physDesc":[{"extent":"9 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1584606657"],"doi":["10.1016/j.ejca.2012.07.002"]},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"December 2012"}],"name":{"displayForm":["Matthias Preusser, Frank Winkler, Laurence Collette, Sven Haller, Sandrine Marreaud, Riccardo Soffietti, Martin Klein, Jaap C. Reijneveld, Jörg-Christian Tonn, Brigitta G. Baumert, Paula Mulvenna, Dirk Schadendorf, Renata Duchnowska, Anna Sophie Berghoff, Nancy Lin, David A. Cameron, Yazid Belkacemi, Jacek Jassem, Damien C. Weber"]},"recId":"1584606657"} | ||
| SRT | |a PREUSSERMATRIALDESIG2012 | ||