Renal BOLD-MRI does not reflect renal function in chronic kidney disease
Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2*) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. T...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 April 2012
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| In: |
Kidney international
Year: 2012, Jahrgang: 81, Heft: 7, Pages: 684-689 |
| ISSN: | 1523-1755 |
| DOI: | 10.1038/ki.2011.455 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/ki.2011.455 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0085253815553702 
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| Verfasserangaben: | Henrik J. Michaely, Linda Metzger, Stefan Haneder, Jan Hansmann, Stefan O. Schoenberg, Ulrike I. Attenberger |
| Zusammenfassung: | Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2*) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was evaluated in 400 patients scheduled for abdominal imaging who underwent transversal blood oxygen level-dependent measurements with a multi-echo gradient-echo sequence with 12 echo times. The loss of phase coherence (T2*) maps were generated in which kidney regions of interest were selected to differentiate the medulla and cortex, and R2* was equated to 1/T2*. Individual R2* values were, in turn, correlated to the eGFR (MDRD formula of 280 patients with available serum creatinine measurements), age, and gender each for 1.5 and 3.0T field-strength scans of 342 patients. At both the field strengths, no significant differences in R2* of the cortex and medulla were found between patient gender, age, eGFR, or between different stages of chronic kidney disease determined using the KDOQI system. Thus, BOLD-MRI of a non-specific patient population failed to discriminate between the patients with various stages of chronic kidney disease. |
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| Beschreibung: | Gesehen am 29.11.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1523-1755 |
| DOI: | 10.1038/ki.2011.455 |