Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis
Aspartimide formation is one of the major obstacles that impedes the solid phase synthesis of large peptides and proteins. Until now, no cost-effective strategy to suppress this side reaction has been developed. Here it is demonstrated that addition of small amounts of organic acids to the standard...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 1, 2012
|
| In: |
Organic letters
Year: 2012, Jahrgang: 14, Heft: 20, Pages: 5218-5221 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/ol3007925 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1021/ol3007925 Verlag, Volltext: https://doi.org/10.1021/ol3007925 
|
| Verfasserangaben: | Tillmann Michels, Rudolf Dölling, Uwe Haberkorn, Walter Mier |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1584623837 | ||
| 003 | DE-627 | ||
| 005 | 20220815071612.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181129s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/ol3007925 |2 doi | |
| 035 | |a (DE-627)1584623837 | ||
| 035 | |a (DE-576)514623837 | ||
| 035 | |a (DE-599)BSZ514623837 | ||
| 035 | |a (OCoLC)1341024663 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Michels, Tillmann |e VerfasserIn |0 (DE-588)1162738332 |0 (DE-627)1026901162 |0 (DE-576)507602293 |4 aut | |
| 245 | 1 | 0 | |a Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis |c Tillmann Michels, Rudolf Dölling, Uwe Haberkorn, Walter Mier |
| 264 | 1 | |c October 1, 2012 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.11.2018 | ||
| 520 | |a Aspartimide formation is one of the major obstacles that impedes the solid phase synthesis of large peptides and proteins. Until now, no cost-effective strategy to suppress this side reaction has been developed. Here it is demonstrated that addition of small amounts of organic acids to the standard Fmoc cleavage agent piperidine efficiently prevents formation of aspartimide side products. This effect is shown to be virtually independent of the acid strength. | ||
| 700 | 1 | |a Dölling, Rudolf |d 1902-1975 |e VerfasserIn |0 (DE-588)123490715 |0 (DE-627)706317920 |0 (DE-576)214861139 |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Mier, Walter |d 1966- |e VerfasserIn |0 (DE-588)12029026X |0 (DE-627)69653567X |0 (DE-576)292141599 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Organic letters |d Washington, DC : ACS, 1999 |g 14(2012), 20, Seite 5218-5221 |h Online-Ressource |w (DE-627)306717662 |w (DE-600)1501522-1 |w (DE-576)082438013 |x 1523-7052 |7 nnas |a Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis |
| 773 | 1 | 8 | |g volume:14 |g year:2012 |g number:20 |g pages:5218-5221 |g extent:4 |a Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/ol3007925 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1021/ol3007925 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181129 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 12029026X |a Mier, Walter |m 12029026X:Mier, Walter |d 910000 |d 911400 |e 910000PM12029026X |e 911400PM12029026X |k 0/910000/ |k 1/910000/911400/ |p 4 |y j | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 1162738332 |a Michels, Tillmann |m 1162738332:Michels, Tillmann |d 140000 |e 140000PM1162738332 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1584623837 |e 3035964963 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1584623837","language":["eng"],"physDesc":[{"extent":"4 S."}],"name":{"displayForm":["Tillmann Michels, Rudolf Dölling, Uwe Haberkorn, Walter Mier"]},"id":{"doi":["10.1021/ol3007925"],"eki":["1584623837"]},"origin":[{"dateIssuedDisp":"October 1, 2012","dateIssuedKey":"2012"}],"person":[{"family":"Michels","role":"aut","display":"Michels, Tillmann","given":"Tillmann"},{"given":"Rudolf","family":"Dölling","display":"Dölling, Rudolf","role":"aut"},{"given":"Uwe","role":"aut","display":"Haberkorn, Uwe","family":"Haberkorn"},{"family":"Mier","role":"aut","display":"Mier, Walter","given":"Walter"}],"title":[{"title":"Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis","title_sort":"Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis"}],"relHost":[{"note":["Gesehen am 25.08.2020"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1999 -"],"title":[{"title_sort":"Organic letters","title":"Organic letters"}],"origin":[{"publisher":"ACS","dateIssuedKey":"1999","dateIssuedDisp":"1999-","publisherPlace":"Washington, DC"}],"id":{"eki":["306717662"],"zdb":["1501522-1"],"issn":["1523-7052"]},"name":{"displayForm":["American Chemical Society"]},"disp":"Acid-mediated prevention of aspartimide formation in solid phase peptide synthesisOrganic letters","language":["eng"],"part":{"issue":"20","pages":"5218-5221","volume":"14","extent":"4","text":"14(2012), 20, Seite 5218-5221","year":"2012"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"306717662"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 29.11.2018"]} | ||
| SRT | |a MICHELSTILACIDMEDIAT1201 | ||