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Full stereochemical determination of ajudazols A and B by bioinformatics gene cluster analysis and total synthesis of ajudazol B by an asymmetric ortholithiation strategy

The stereochemical determination of the potent respiratory chain inhibitors ajudazols A and B and the total synthesis of ajudazol B are reported. Configurational assignment was exclusively based on biosynthetic gene cluster analysis of both ketoreductase domains for hydroxyl-bearing stereocenters an...

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Bibliographic Details
Main Authors: Essig, Sebastian (Author) , Bretzke, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 28 November 2012
In: Journal of the American Chemical Society
Year: 2012, Volume: 134, Issue: 47, Pages: 19362-19365
ISSN:1520-5126
DOI:10.1021/ja309685n
Online Access:Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1021/ja309685n
Verlag, Pay-per-use, Volltext: https://doi.org/10.1021/ja309685n
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Author Notes:Sebastian Essig, Sebastian Bretzke, Rolf Müller, and Dirk Menche

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