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Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9

Anti-CRISPR proteins are powerful tools for CRISPR–Cas9 regulation; the ability to precisely modulate their activity could facilitate spatiotemporally confined genome perturbations and uncover fundamental aspects of CRISPR biology. We engineered optogenetic anti-CRISPR variants comprising hybrids of...

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Hauptverfasser: Bubeck, Felix (VerfasserIn) , Hoffmann, Mareike (VerfasserIn) , Bietz, Andreas (VerfasserIn) , Waldhauer, Max (VerfasserIn) , Börner, Kathleen (VerfasserIn) , Fakhiri, Julia (VerfasserIn) , Schmelas, Carolin (VerfasserIn) , Dietz, Laura (VerfasserIn) , Grimm, Dirk (VerfasserIn) , Eils, Roland (VerfasserIn) , Niopek, Dominik (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 30 October 2018
In: Nature methods
Year: 2018, Jahrgang: 15, Heft: 11, Pages: 924-927
ISSN:1548-7105
DOI:10.1038/s41592-018-0178-9
Online-Zugang:Resolving-System, Volltext: http://dx.doi.org/10.1038/s41592-018-0178-9
Verlag, Volltext: https://www.nature.com/articles/s41592-018-0178-9
Volltext
Verfasserangaben:Felix Bubeck, Mareike D. Hoffmann, Zander Harteveld, Sabine Aschenbrenner, Andreas Bietz, Max C. Waldhauer, Kathleen Börner, Julia Fakhiri, Carolin Schmelas, Laura Dietz, Dirk Grimm, Bruno E. Correia, Roland Eils and Dominik Niopek

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