Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis
Metastatic progression remains a major burden for cancer patients and is associated with eventual resistance to prevailing therapies such as chemotherapy. Here, we reveal how chemotherapy induces an extracellular matrix (ECM), wound healing, and stem cell network in cancer cells via the c‐Jun N‐term...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 October 2018
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| In: |
EMBO molecular medicine
Year: 2018, Jahrgang: 10, Heft: 10 |
| ISSN: | 1757-4684 |
| DOI: | 10.15252/emmm.201809003 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.15252/emmm.201809003 Verlag, kostenfrei, Volltext: http://embomolmed.embopress.org/content/10/10/e9003 
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| Verfasserangaben: | Jacob Insua‐Rodríguez, Maren Pein, Tsunaki Hongu, Jasmin Meier, Arnaud Descot, Camille M. Lowy, Etienne De Braekeleer, Hans-Peter Sinn, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss & Thordur Oskarsson |
MARC
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| 520 | |a Metastatic progression remains a major burden for cancer patients and is associated with eventual resistance to prevailing therapies such as chemotherapy. Here, we reveal how chemotherapy induces an extracellular matrix (ECM), wound healing, and stem cell network in cancer cells via the c‐Jun N‐terminal kinase (JNK) pathway, leading to reduced therapeutic efficacy. | ||
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