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Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis

Metastatic progression remains a major burden for cancer patients and is associated with eventual resistance to prevailing therapies such as chemotherapy. Here, we reveal how chemotherapy induces an extracellular matrix (ECM), wound healing, and stem cell network in cancer cells via the c‐Jun N‐term...

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Hauptverfasser: Insua-Rodríguez, Jacob (VerfasserIn) , Lowy, Camille (VerfasserIn) , Sinn, Peter (VerfasserIn) , Spaich, Saskia (VerfasserIn) , Sütterlin, Marc (VerfasserIn) , Schneeweiss, Andreas (VerfasserIn) , Oskarsson, Thordur (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1 October 2018
In: EMBO molecular medicine
Year: 2018, Jahrgang: 10, Heft: 10
ISSN:1757-4684
DOI:10.15252/emmm.201809003
Online-Zugang:Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.15252/emmm.201809003
Verlag, kostenfrei, Volltext: http://embomolmed.embopress.org/content/10/10/e9003
Volltext
Verfasserangaben:Jacob Insua‐Rodríguez, Maren Pein, Tsunaki Hongu, Jasmin Meier, Arnaud Descot, Camille M. Lowy, Etienne De Braekeleer, Hans-Peter Sinn, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss & Thordur Oskarsson
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Zusammenfassung:Metastatic progression remains a major burden for cancer patients and is associated with eventual resistance to prevailing therapies such as chemotherapy. Here, we reveal how chemotherapy induces an extracellular matrix (ECM), wound healing, and stem cell network in cancer cells via the c‐Jun N‐terminal kinase (JNK) pathway, leading to reduced therapeutic efficacy.
Beschreibung:Gesehen am 07.12.2018
Beschreibung:Online Resource
ISSN:1757-4684
DOI:10.15252/emmm.201809003

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