Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group
The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities such as t(4;14), del(17/17p), t(14;16), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis. The progno...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 21, 2016
|
| In: |
Blood
Year: 2016, Jahrgang: 127, Heft: 24, Pages: 2955-2962 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2016-01-631200 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1182/blood-2016-01-631200 Verlag, Volltext: http://www.bloodjournal.org/content/127/24/2955 
|
| Verfasserangaben: | Pieter Sonneveld, Hervé Avet-Loiseau, Sagar Lonial, Saad Usmani, David Siegel, Kenneth C. Anderson, Wee-Joo Chng, Philippe Moreau, Michel Attal, Robert A. Kyle, Jo Caers, Jens Hillengass, Jesús San Miguel, Niels W.C.J. van de Donk, Hermann Einsele, Joan Bladé, Brian G.M. Durie, Hartmut Goldschmidt, María-Victoria Mateos, Antonio Palumbo, and Robert Orlowski |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1585091529 | ||
| 003 | DE-627 | ||
| 005 | 20230427161343.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181211s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2016-01-631200 |2 doi | |
| 035 | |a (DE-627)1585091529 | ||
| 035 | |a (DE-576)515091529 | ||
| 035 | |a (DE-599)BSZ515091529 | ||
| 035 | |a (OCoLC)1341026924 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sonneveld, Pieter |d 1951- |e VerfasserIn |0 (DE-588)114640378X |0 (DE-627)100791730X |0 (DE-576)186122195 |4 aut | |
| 245 | 1 | 0 | |a Treatment of multiple myeloma with high-risk cytogenetics |b a consensus of the International Myeloma Working Group |c Pieter Sonneveld, Hervé Avet-Loiseau, Sagar Lonial, Saad Usmani, David Siegel, Kenneth C. Anderson, Wee-Joo Chng, Philippe Moreau, Michel Attal, Robert A. Kyle, Jo Caers, Jens Hillengass, Jesús San Miguel, Niels W.C.J. van de Donk, Hermann Einsele, Joan Bladé, Brian G.M. Durie, Hartmut Goldschmidt, María-Victoria Mateos, Antonio Palumbo, and Robert Orlowski |
| 264 | 1 | |c March 21, 2016 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.12.2018 | ||
| 520 | |a The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities such as t(4;14), del(17/17p), t(14;16), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis. The prognosis of patients showing these abnormalities may vary with the choice of therapy. Treatment strategies have shown promise for HR cytogenetic diseases, such as proteasome inhibition in combination with lenalidomide/pomalidomide, double autologous stem cell transplant plus bortezomib, or combination of immunotherapy with lenalidomide or pomalidomide. Careful analysis of cytogenetic subgroups in trials comparing different treatments remains an important goal. Cross-trial comparisons may provide insight into the effect of new drugs in patients with cytogenetic abnormalities. However, to achieve this, consensus on definitions of analytical techniques, proportion of abnormal cells, and treatment regimens is needed. Based on data available today, bortezomib and carfilzomib treatment appear to improve complete response, progression-free survival, and overall survival in t(4;14) and del(17/17p), whereas lenalidomide may be associated with improved progression-free survival in t(4;14) and del(17/17p). Patients with multiple adverse cytogenetic abnormalities do not benefit from these agents. FISH data are implemented in the revised International Staging System for risk stratification. | ||
| 700 | 1 | |a Hillengaß, Jens |d 1974- |e VerfasserIn |0 (DE-588)124918549 |0 (DE-627)368073823 |0 (DE-576)294568298 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 127(2016), 24, Seite 2955-2962 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a Treatment of multiple myeloma with high-risk cytogenetics a consensus of the International Myeloma Working Group |
| 773 | 1 | 8 | |g volume:127 |g year:2016 |g number:24 |g pages:2955-2962 |g extent:8 |a Treatment of multiple myeloma with high-risk cytogenetics a consensus of the International Myeloma Working Group |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1182/blood-2016-01-631200 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.bloodjournal.org/content/127/24/2955 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181211 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |e 910000PG102258023X |k 0/910000/ |p 18 | ||
| 998 | |g 124918549 |a Hillengaß, Jens |m 124918549:Hillengaß, Jens |d 910000 |d 910100 |e 910000PH124918549 |e 910100PH124918549 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 999 | |a KXP-PPN1585091529 |e 3037400641 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"role":"aut","given":"Pieter","display":"Sonneveld, Pieter","family":"Sonneveld"},{"given":"Jens","role":"aut","display":"Hillengaß, Jens","family":"Hillengaß"},{"role":"aut","given":"Hartmut","display":"Goldschmidt, Hartmut","family":"Goldschmidt"}],"name":{"displayForm":["Pieter Sonneveld, Hervé Avet-Loiseau, Sagar Lonial, Saad Usmani, David Siegel, Kenneth C. Anderson, Wee-Joo Chng, Philippe Moreau, Michel Attal, Robert A. Kyle, Jo Caers, Jens Hillengass, Jesús San Miguel, Niels W.C.J. van de Donk, Hermann Einsele, Joan Bladé, Brian G.M. Durie, Hartmut Goldschmidt, María-Victoria Mateos, Antonio Palumbo, and Robert Orlowski"]},"physDesc":[{"extent":"8 S."}],"recId":"1585091529","relHost":[{"corporate":[{"role":"isb","display":"American Society of Hematology"}],"language":["eng"],"titleAlt":[{"title":"Blood online"}],"part":{"pages":"2955-2962","year":"2016","text":"127(2016), 24, Seite 2955-2962","issue":"24","volume":"127","extent":"8"},"title":[{"title":"Blood","title_sort":"Blood","subtitle":"journal of the American Society of Hematology"}],"origin":[{"publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946","dateIssuedDisp":"1946-","publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif."}],"pubHistory":["1.1946 -"],"note":["Gesehen am 21.04.2023"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Treatment of multiple myeloma with high-risk cytogenetics a consensus of the International Myeloma Working GroupBlood","physDesc":[{"extent":"Online-Ressource"}],"recId":"266886647","id":{"issn":["1528-0020"],"zdb":["1468538-3"],"eki":["266886647"]}}],"id":{"eki":["1585091529"],"doi":["10.1182/blood-2016-01-631200"]},"note":["Gesehen am 11.12.2018"],"origin":[{"dateIssuedDisp":"March 21, 2016","dateIssuedKey":"2016"}],"title":[{"title":"Treatment of multiple myeloma with high-risk cytogenetics","subtitle":"a consensus of the International Myeloma Working Group","title_sort":"Treatment of multiple myeloma with high-risk cytogenetics"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a SONNEVELDPTREATMENTO2120 | ||