Post-Turing tissue pattern formation: advent of mechanochemistry
Chemical and mechanical pattern formation is fundamental during embryogenesis and tissue development. Yet, the underlying molecular and cellular mechanisms are still elusive in many cases. Most current theories assume that tissue development is driven by chemical processes: either as a sequence of c...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 3, 2018
|
| In: |
PLoS Computational Biology
Year: 2018, Jahrgang: 14, Heft: 7, Pages: e1006259 |
| ISSN: | 1553-7358 |
| DOI: | 10.1371/journal.pcbi.1006259 |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1371/journal.pcbi.1006259 Verlag, Volltext: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006259 
|
| Verfasserangaben: | Felix Brinkmann, Moritz Mercker, Thomas Richter, Anna Marciniak-Czochra |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1585616524 | ||
| 003 | DE-627 | ||
| 005 | 20220815082624.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181217s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pcbi.1006259 |2 doi | |
| 035 | |a (DE-627)1585616524 | ||
| 035 | |a (DE-576)515616524 | ||
| 035 | |a (DE-599)BSZ515616524 | ||
| 035 | |a (OCoLC)1341031011 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 084 | |a 27 |2 sdnb | ||
| 100 | 1 | |a Brinkmann, Felix |d 1986- |e VerfasserIn |0 (DE-588)1035781182 |0 (DE-627)74955763X |0 (DE-576)383533651 |4 aut | |
| 245 | 1 | 0 | |a Post-Turing tissue pattern formation |b advent of mechanochemistry |c Felix Brinkmann, Moritz Mercker, Thomas Richter, Anna Marciniak-Czochra |
| 264 | 1 | |c July 3, 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 17.12.2018 | ||
| 520 | |a Chemical and mechanical pattern formation is fundamental during embryogenesis and tissue development. Yet, the underlying molecular and cellular mechanisms are still elusive in many cases. Most current theories assume that tissue development is driven by chemical processes: either as a sequence of chemical patterns each depending on the previous one, or by patterns spontaneously arising from specific chemical interactions (such as “Turing-patterns”). Within both theories, mechanical patterns are usually regarded as passive by-products of chemical pre-patters. However, several experiments question these theories, and an increasing number of studies shows that tissue mechanics can actively influence chemical patterns during development. In this study, we thus focus on the interplay between chemical and mechanical processes during tissue development. On one hand, based on recent experimental data, we develop new mechanochemical simulation models of evolving tissues, in which the full 3D representation of the tissue appears to be critical for obtaining a realistic mechanochemical behaviour. The presented modelling approach is flexible and numerically studied using state of the art finite element methods. Thus, it may serve as a basis to combine simulations with new experimental methods in tissue development. On the other hand, we apply the developed approach and demonstrate that even simple interactions between tissue mechanics and chemistry spontaneously lead to robust and complex mechanochemical patterns. Especially, we demonstrate that the main contradictions arising in the framework of purely chemical theories are naturally and automatically resolved using the mechanochemical patterning theory. | ||
| 650 | 4 | |a Biophysical simulations | |
| 650 | 4 | |a Cellular types | |
| 650 | 4 | |a Deformation | |
| 650 | 4 | |a Embryonic pattern formation | |
| 650 | 4 | |a Finite element analysis | |
| 650 | 4 | |a Morphogens | |
| 650 | 4 | |a Pattern formation | |
| 650 | 4 | |a Tissue mechanics | |
| 700 | 1 | |a Mercker, Moritz |e VerfasserIn |0 (DE-588)1025652657 |0 (DE-627)72444548X |0 (DE-576)337324948 |4 aut | |
| 700 | 1 | |a Richter, Thomas |e VerfasserIn |0 (DE-588)1025367154 |0 (DE-627)722167822 |0 (DE-576)370268547 |4 aut | |
| 700 | 1 | |a Marciniak-Czochra, Anna |d 1974- |e VerfasserIn |0 (DE-588)1044379626 |0 (DE-627)771928432 |0 (DE-576)397031505 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS Computational Biology |d San Francisco, Calif. : Public Library of Science, 2005 |g 14(2018), 7, Seite e1006259 |h Online-Ressource |w (DE-627)491436017 |w (DE-600)2193340-6 |w (DE-576)273890492 |x 1553-7358 |7 nnas |
| 773 | 1 | 8 | |g volume:14 |g year:2018 |g number:7 |g pages:e1006259 |a Post-Turing tissue pattern formation advent of mechanochemistry |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pcbi.1006259 |x Resolving-System |x Verlag |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006259 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20181217 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1044379626 |a Marciniak-Czochra, Anna |m 1044379626:Marciniak-Czochra, Anna |d 110000 |d 110200 |d 110000 |d 110400 |e 110000PM1044379626 |e 110200PM1044379626 |e 110000PM1044379626 |e 110400PM1044379626 |k 0/110000/ |k 1/110000/110200/ |k 0/110000/ |k 1/110000/110400/ |p 4 |y j | ||
| 998 | |g 1025367154 |a Richter, Thomas |m 1025367154:Richter, Thomas |p 3 | ||
| 998 | |g 1025652657 |a Mercker, Moritz |m 1025652657:Mercker, Moritz |d 110000 |d 110200 |d 110000 |d 110400 |e 110000PM1025652657 |e 110200PM1025652657 |e 110000PM1025652657 |e 110400PM1025652657 |k 0/110000/ |k 1/110000/110200/ |k 0/110000/ |k 1/110000/110400/ |p 2 | ||
| 998 | |g 1035781182 |a Brinkmann, Felix |m 1035781182:Brinkmann, Felix |d 110000 |d 110200 |d 110000 |d 110400 |e 110000PB1035781182 |e 110200PB1035781182 |e 110000PB1035781182 |e 110400PB1035781182 |k 0/110000/ |k 1/110000/110200/ |k 0/110000/ |k 1/110000/110400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1585616524 |e 3038493929 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Brinkmann","display":"Brinkmann, Felix","role":"aut","given":"Felix"},{"role":"aut","given":"Moritz","family":"Mercker","display":"Mercker, Moritz"},{"family":"Richter","display":"Richter, Thomas","role":"aut","given":"Thomas"},{"family":"Marciniak-Czochra","display":"Marciniak-Czochra, Anna","role":"aut","given":"Anna"}],"note":["Gesehen am 17.12.2018"],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"July 3, 2018"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Post-Turing tissue pattern formation","subtitle":"advent of mechanochemistry","title_sort":"Post-Turing tissue pattern formation"}],"language":["eng"],"name":{"displayForm":["Felix Brinkmann, Moritz Mercker, Thomas Richter, Anna Marciniak-Czochra"]},"recId":"1585616524","id":{"eki":["1585616524"],"doi":["10.1371/journal.pcbi.1006259"]},"relHost":[{"id":{"zdb":["2193340-6"],"eki":["491436017"],"issn":["1553-7358"]},"name":{"displayForm":["publ. by the Public Library of Science (PLoS) in association with the International Society for Computational Biology (ISCB)"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2005 -"],"recId":"491436017","origin":[{"dateIssuedDisp":"2005-","publisherPlace":"San Francisco, Calif.","dateIssuedKey":"2005","publisher":"Public Library of Science"}],"note":["Gesehen am 23. November 2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"PLoS Computational Biology","subtitle":"a new community journal","title_sort":"PLoS Computational Biology"}],"part":{"year":"2018","issue":"7","text":"14(2018), 7, Seite e1006259","pages":"e1006259","volume":"14"},"language":["eng"],"corporate":[{"role":"aut","display":"Public Library of Science"}],"disp":"Public Library of SciencePLoS Computational Biology"}]} | ||
| SRT | |a BRINKMANNFPOSTTURING3201 | ||