The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma
Pilocytic astrocytoma (PA) is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of PAs. The senescence-associated secretory phenotype (SASP) has been shown to r...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 March 2019
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| In: |
Clinical cancer research
Year: 2019, Jahrgang: 25, Heft: 6, Pages: 1851-1866 |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-18-1965 |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1158/1078-0432.CCR-18-1965 Verlag, Volltext: http://clincancerres.aacrjournals.org/content/early/2018/12/07/1078-0432.CCR-18-1965 
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| Verfasserangaben: | Juliane L. Buhl, Florian Selt, Thomas Hielscher, Romain Guiho, Jonas Ecker, Felix Sahm, Johannes Ridinger, Dennis Riehl, Diren Usta, Britta Ismer, Alexander C. Sommerkamp, J.P. Martinez-Babera, Annika K. Wefers, Marc Remke, Daniel Picard, Stefan Pusch, Jan Gronych, Ina Oehme, Cornelis M. van Tilburg, Marcel Kool, Daniela Kuhn, David Capper, Andreas von Deimling, Martin Schuhmann, Christel Herold-Mende, Andrey Korshunov, Tilman Brummer, Stefan M. Pfister, David T.W. Jones, Olaf Witt and Till Milde |
MARC
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| 520 | |a Pilocytic astrocytoma (PA) is the most common childhood brain tumor, characterized by constitutive MAPK activation. MAPK signaling induces oncogene-induced senescence (OIS), which may cause unpredictable growth behavior of PAs. The senescence-associated secretory phenotype (SASP) has been shown to regulate OIS, but its role in PA remains unknown. | ||
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