RIPping the skin apart: necroptosis signaling in toxic epidermal necrolysis
Toxic epidermal necrolysis (TEN) is a rare but potentially fatal drug hypersensitivity reaction. Although a number of pathophysiological hints have been identified over the past decade, details of the effector mechanisms within the skin remain obscure. A novel study by Kim et al. now sheds light on...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2015
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| In: |
The journal of investigative dermatology
Year: 2015, Volume: 135, Issue: 8, Pages: 1940-1943 |
| ISSN: | 1523-1747 |
| DOI: | 10.1038/jid.2015.159 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/jid.2015.159 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022202X15390539 
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| Author Notes: | Diana Panayotova-Dimitrova, Maria Feoktistova, Martin Leverkus |
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| 520 | |a Toxic epidermal necrolysis (TEN) is a rare but potentially fatal drug hypersensitivity reaction. Although a number of pathophysiological hints have been identified over the past decade, details of the effector mechanisms within the skin remain obscure. A novel study by Kim et al. now sheds light on its pathophysiology. The investigators demonstrate convincingly that receptor-interacting kinase 3 (RIPK3) levels are upregulated substantially in the lesional skin of patients with TEN and that this is followed by the generation of reactive oxygen species, activation of mixed lineage kinase-like protein, and subsequent necroptotic cell death of keratinocytes. These data suggest that therapies that interfere with RIPK3 activation and necroptosis induction could benefit patients with TEN. | ||
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