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Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

During collective cell migration, how leader cells emerge is poorly understood. Here, the authors find that small groups of mechanically-interacting follower cells pull on the future leaders to stochastically elect them to their fate.

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Bibliographische Detailangaben
Hauptverfasser: Vishwakarma, Medhavi (VerfasserIn) , Probst, Dimitri (VerfasserIn) , Schwarz, Ulrich S. (VerfasserIn) , Spatz, Joachim P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 27 August 2018
In: Nature Communications
Year: 2018, Jahrgang: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-05927-6
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/s41467-018-05927-6
Verlag, Volltext: https://www.nature.com/articles/s41467-018-05927-6
Volltext
Verfasserangaben:Medhavi Vishwakarma, Jacopo Di Russo, Dimitri Probst, Ulrich S. Schwarz, Tamal Das & Joachim P. Spatz

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