A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We c...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Human molecular genetics
Year: 2015, Volume: 25, Issue: 2, Pages: 358-370 |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/ddv454 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1093/hmg/ddv454 Verlag, Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/hmg/article/25/2/358/2384455 
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| Author Notes: | Paul S. de Vries, Daniel I. Chasman, Maria Sabater-Lleal, Ming-Huei Chen, Jennifer E. Huffman, Maristella Steri, Weihong Tang, Alexander Teumer, Riccardo E. Marioni, Vera Grossmann, Jouke J. Hottenga, Stella Trompet, Martina Müller-Nurasyid, Jing Hua Zhao, Jennifer A. Brody, Marcus E. Kleber, Xiuqing Guo, Jie Jin Wang, Paul L. Auer, John R. Attia, Lisa R. Yanek, Tarunveer S. Ahluwalia, Jari Lahti, Cristina Venturini, Toshiko Tanaka, Lawrence F. Bielak, Peter K. Joshi, Ares Rocanin-Arjo, Ivana Kolcic, Pau Navarro, Lynda M. Rose, Christopher Oldmeadow, Helene Riess, Johanna Mazur, Saonli Basu, Anuj Goel, Qiong Yang, Mohsen Ghanbari, Gonneke Willemsen, Ann Rumley, Edoardo Fiorillo, Anton J.M. de Craen, Anne Grotevendt, Robert Scott, Kent D. Taylor, Graciela E. Delgado, Jie Yao, Annette Kifley, Charles Kooperberg, Rehan Qayyum, Lorna M. Lopez, Tina L. Berentzen, Katri Räikkönen, Massimo Mangino, Stefania Bandinelli, Patricia A. Peyser, Sarah Wild, David-Alexandre Trégouët, Alan F. Wright, Jonathan Marten, Tatijana Zemunik, Alanna C. Morrison, Bengt Sennblad, Geoffrey Tofler, Moniek P.M. de Maat, Eco J.C. de Geus, Gordon D. Lowe, Magdalena Zoledziewska, Naveed Sattar, Harald Binder, Uwe Völker, Melanie Waldenberger, Kay-Tee Khaw, Barbara Mcknight, Jie Huang, Nancy S. Jenny, Elizabeth G. Holliday, Lihong Qi, Mark G. Mcevoy, Diane M. Becker, John M. Starr, Antti-Pekka Sarin, Pirro G. Hysi, Dena G. Hernandez, Min A. Jhun, Harry Campbell, Anders Hamsten, Fernando Rivadeneira, Wendy L. Mcardle, P. Eline Slagboom, Tanja Zeller, Wolfgang Koenig, Bruce M. Psaty, Talin Haritunians, Jingmin Liu, Aarno Palotie, André G. Uitterlinden, David J. Stott, Albert Hofman, Oscar H. Franco, Ozren Polasek, Igor Rudan, Pierre-Emmanuel Morange, James F. Wilson, Sharon L.R. Kardia, Luigi Ferrucci, Tim D. Spector, Johan G. Eriksson, Torben Hansen, Ian J. Deary, Lewis C. Becker, Rodney J. Scott, Paul Mitchell, Winfried März, Nick J. Wareham, Annette Peters, Andreas Greinacher, Philipp S. Wild, J. Wouter Jukema, Dorret I. Boomsma, Caroline Hayward, Francesco Cucca, Russell Tracy, Hugh Watkins, Alex P. Reiner, Aaron R. Folsom, Paul M. Ridker, Christopher J. O'Donnell, Nicholas L. Smith, David P. Strachan and Abbas Dehghan |
| Summary: | Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration. |
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| Item Description: | Gesehen am 10.01.2019 Advance Access Publication Date: 10 November 2015 |
| Physical Description: | Online Resource |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/ddv454 |