Transcription of inflammatory cytokine TNFα is upregulated in retinal angiogenesis under hyperoxia
Background/Aims: Hypoxia induces angiogenesis while hyperoxia promotes vasoregression in the retina. We investigated herein the effect of prolonged hyperoxia on retinal angiogenesis and the underlying mechanism in an oxygen-induced retinopathy (OIR) model. Methods: Vascular morphology was quantified...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 11, 2016
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| In: |
Cellular physiology and biochemistry
Year: 2016, Volume: 39, Issue: 2, Pages: 573-583 |
| ISSN: | 1421-9778 |
| DOI: | 10.1159/000445649 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1159/000445649 Verlag, Volltext: https://www-karger-com.ezproxy.medma.uni-heidelberg.de/Article/FullText/445649 
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| Author Notes: | Yuxi Feng, Shalini Gross, Anupriya Chatterjee, Yumei Wang, Jihong Lin, Hans-Peter Hammes |
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| 245 | 1 | 0 | |a Transcription of inflammatory cytokine TNFα is upregulated in retinal angiogenesis under hyperoxia |c Yuxi Feng, Shalini Gross, Anupriya Chatterjee, Yumei Wang, Jihong Lin, Hans-Peter Hammes |
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| 520 | |a Background/Aims: Hypoxia induces angiogenesis while hyperoxia promotes vasoregression in the retina. We investigated herein the effect of prolonged hyperoxia on retinal angiogenesis and the underlying mechanism in an oxygen-induced retinopathy (OIR) model. Methods: Vascular morphology was quantified in whole-mount retina from the mice subjected to the conventional OIR model (c-OIR) or the OIR model with prolonged hyperoxia (p-OIR). Expressions of genes related to angiogenesis were determined by real-time PCR. Results: p-OIR retinas showed few intraretinal neovascular tufts at the border of avascular zones, lacking preretinal neovascularization, whereas c-OIR retinas had numerous preretinal neovascularizations. p-OIR retinas demonstrated outgrowth of capillaries in the deep layers despite persistent hyperoxia and possess a larger avascular zone compared with the c-OIR retinas. The capillaries in the p-OIR retinas were well-formed in contrast to those in the c-OIR retinas. p-OIR retinas expressed significantly higher TNFα (∼4 fold) than c-OIR retinas. The expression of vascular endothelial growth factor, Erythropoietin, Angiopoietin 1 and 2 remained unchanged. Conclusion: Our data demonstrate that TNFα transcription is increased in hyperoxia-promoted retinal angiogenesis, implicating it, in association with low VEGF levels, as a possible proponent in retinal angiogenesis under hyperoxia. | ||
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