Buchumschlag

Morc1 knockout evokes a depression-like phenotype in mice

Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behav...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schmidt, Michaela (VerfasserIn) , Deuschle, Michael (VerfasserIn) , Gass, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2016
In: Behavioural brain research
Year: 2015, Jahrgang: 296, Pages: 7-14
ISSN:1872-7549
DOI:10.1016/j.bbr.2015.08.005
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.bbr.2015.08.005
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0166432815301388
Volltext
Verfasserangaben:M. Schmidt, C. Brandwein, A. Luoni, P. Sandrini, T. Calzoni, M. Deuschle, F. Cirulli, M.A. Riva, P. Gass

MARC

LEADER 00000caa a2200000 c 4500
001 1586359169
003 DE-627
005 20220815091630.0
007 cr uuu---uuuuu
008 190117r20162015xx |||||o 00| ||eng c
024 7 |a 10.1016/j.bbr.2015.08.005  |2 doi 
035 |a (DE-627)1586359169 
035 |a (DE-576)516359169 
035 |a (DE-599)BSZ516359169 
035 |a (OCoLC)1341033644 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Schmidt, Michaela  |e VerfasserIn  |0 (DE-588)1155485106  |0 (DE-627)1017751358  |0 (DE-576)501671234  |4 aut 
245 1 0 |a Morc1 knockout evokes a depression-like phenotype in mice  |c M. Schmidt, C. Brandwein, A. Luoni, P. Sandrini, T. Calzoni, M. Deuschle, F. Cirulli, M.A. Riva, P. Gass 
264 1 |c 2016 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 17.01.2019 
500 |a Available online 11 August 2015 
520 |a Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behavioral level. In the present study, we examined the effects of a Morc1 loss of function mutation in female C57BL/6N mice on behavioral correlates of mood disorders like the Forced Swim Test, the Learned Helplessness Paradigm, O-Maze and Dark-Light-Box. We could show that Morc1-/- mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior were detectable. CORT plasma levels did not differ significantly between Morc1-/- mice and their wildtype littermates, yet - surprisingly - total Bdnf mRNA-levels in the hippocampus were up-regulated in Morc1-/- animals. Although further work would be clarifying, Morc1-/- mice seem to be a promising epigenetically validated mouse model for depression associated with early life stress. 
534 |c 2015 
650 4 |a Depression 
650 4 |a Early life stress 
650 4 |a Epigenetics 
650 4 |a Transgenic mice 
700 1 |a Deuschle, Michael  |d 1963-  |e VerfasserIn  |0 (DE-588)1029068801  |0 (DE-627)732393086  |0 (DE-576)376532408  |4 aut 
700 1 |a Gass, Peter  |d 1963-  |e VerfasserIn  |0 (DE-588)13015945X  |0 (DE-627)492009694  |0 (DE-576)298033771  |4 aut 
773 0 8 |i Enthalten in  |t Behavioural brain research  |d Amsterdam : Elsevier, 1980  |g 296(2016), Seite 7-14  |h Online-Ressource  |w (DE-627)320512746  |w (DE-600)2013604-3  |w (DE-576)094085714  |x 1872-7549  |7 nnas  |a Morc1 knockout evokes a depression-like phenotype in mice 
773 1 8 |g volume:296  |g year:2016  |g pages:7-14  |g extent:8  |a Morc1 knockout evokes a depression-like phenotype in mice 
856 4 0 |u http://dx.doi.org/10.1016/j.bbr.2015.08.005  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0166432815301388  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190117 
993 |a Article 
994 |a 2016 
998 |g 13015945X  |a Gass, Peter  |m 13015945X:Gass, Peter  |d 60000  |e 60000PG13015945X  |k 0/60000/  |p 9  |y j 
998 |g 1029068801  |a Deuschle, Michael  |m 1029068801:Deuschle, Michael  |d 60000  |e 60000PD1029068801  |k 0/60000/  |p 6 
999 |a KXP-PPN1586359169  |e 3046012233 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"Morc1 knockout evokes a depression-like phenotype in mice","title_sort":"Morc1 knockout evokes a depression-like phenotype in mice"}],"relHost":[{"part":{"pages":"7-14","extent":"8","volume":"296","text":"296(2016), Seite 7-14","year":"2016"},"language":["eng"],"title":[{"title_sort":"Behavioural brain research","title":"Behavioural brain research","subtitle":"an international journal"}],"pubHistory":["1.1980 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"320512746","origin":[{"publisherPlace":"Amsterdam","dateIssuedKey":"1980","publisher":"Elsevier","dateIssuedDisp":"1980-"}],"note":["Gesehen am 16.11.2020"],"disp":"Morc1 knockout evokes a depression-like phenotype in miceBehavioural brain research","id":{"issn":["1872-7549"],"zdb":["2013604-3"],"eki":["320512746"]},"physDesc":[{"extent":"Online-Ressource"}]}],"note":["Gesehen am 17.01.2019","Available online 11 August 2015"],"id":{"doi":["10.1016/j.bbr.2015.08.005"],"eki":["1586359169"]},"physDesc":[{"extent":"8 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1586359169","origin":[{"dateIssuedDisp":"2016","dateIssuedKey":"2016"}],"person":[{"role":"aut","given":"Michaela","display":"Schmidt, Michaela","family":"Schmidt"},{"family":"Deuschle","display":"Deuschle, Michael","role":"aut","given":"Michael"},{"display":"Gass, Peter","role":"aut","given":"Peter","family":"Gass"}],"name":{"displayForm":["M. Schmidt, C. Brandwein, A. Luoni, P. Sandrini, T. Calzoni, M. Deuschle, F. Cirulli, M.A. Riva, P. Gass"]}} 
SRT |a SCHMIDTMICMORC1KNOCK2016 

Ähnliche Einträge