Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice
The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infe...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 6, 2018
|
| In: |
PLoS pathogens
Year: 2018, Jahrgang: 14, Heft: 12 |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1007464 |
| Online-Zugang: | Resolving-System, Volltext: http://dx.doi.org/10.1371/journal.ppat.1007464 Verlag, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007464 
|
| Verfasserangaben: | Dwain G. van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1586493752 | ||
| 003 | DE-627 | ||
| 005 | 20230427034212.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190123s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.ppat.1007464 |2 doi | |
| 035 | |a (DE-627)1586493752 | ||
| 035 | |a (DE-576)516493752 | ||
| 035 | |a (DE-599)BSZ516493752 | ||
| 035 | |a (OCoLC)1341033998 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zyl, Dwain George van |e VerfasserIn |0 (DE-588)1175226084 |0 (DE-627)104613468X |0 (DE-576)51613745X |4 aut | |
| 245 | 1 | 0 | |a Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice |c Dwain G. van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse |
| 264 | 1 | |c December 6, 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.01.2019 | ||
| 520 | |a The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. To this end, we generated highly immunogenic particles that contain antigens from both these cycles. In addition to stimulating EBV-specific T cells that recognize lytic or latent proteins, we show that the immunogenic particles enable the ex vivo expansion of cytolytic EBV-specific T cells that efficiently control EBV-infected B cells, preventing their outgrowth. Lastly, we show that immunogenic particles containing the latent protein EBNA1 afford significant protection against wild-type EBV in a humanized mouse model. Vaccines that include antigens which predominate throughout the EBV life cycle are likely to enhance their ability to protect against EBV infection. | ||
| 650 | 4 | |a Antibodies | |
| 650 | 4 | |a Antigens | |
| 650 | 4 | |a B cells | |
| 650 | 4 | |a Cytotoxic T cells | |
| 650 | 4 | |a Epstein-Barr virus | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a T cells | |
| 650 | 4 | |a Vaccination and immunization | |
| 700 | 1 | |a Tsai, Ming-Han |d 1982- |e VerfasserIn |0 (DE-588)1074144465 |0 (DE-627)830319476 |0 (DE-576)437530892 |4 aut | |
| 700 | 1 | |a Shumilov, Anatoliy |d 1988- |e VerfasserIn |0 (DE-588)1140255843 |0 (DE-627)898432634 |0 (DE-576)493752781 |4 aut | |
| 700 | 1 | |a Schlehe, Bettina |d 1974- |e VerfasserIn |0 (DE-588)122373448 |0 (DE-627)081905998 |0 (DE-576)293242631 |4 aut | |
| 700 | 1 | |a Fluhr, Herbert |d 1978- |e VerfasserIn |0 (DE-588)13151086X |0 (DE-627)707650542 |0 (DE-576)250372185 |4 aut | |
| 700 | 1 | |a Delecluse, Henri-Jacques |d 1964- |e VerfasserIn |0 (DE-588)1162647620 |0 (DE-627)1026818125 |0 (DE-576)507558294 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS pathogens |d Lawrence, Kan. : PLoS, 2005 |g 14 (2018,12) Artikel-Nummer e1007464, 23 Seiten |h Online-Ressource |w (DE-627)501074422 |w (DE-600)2205412-1 |w (DE-576)273890530 |x 1553-7374 |7 nnas |
| 773 | 1 | 8 | |g volume:14 |g year:2018 |g number:12 |a Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.ppat.1007464 |x Resolving-System |x Verlag |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007464 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190123 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1162647620 |a Delecluse, Henri-Jacques |m 1162647620:Delecluse, Henri-Jacques |d 50000 |e 50000PD1162647620 |k 0/50000/ |p 9 |y j | ||
| 998 | |g 13151086X |a Fluhr, Herbert |m 13151086X:Fluhr, Herbert |d 910000 |d 910400 |e 910000PF13151086X |e 910400PF13151086X |k 0/910000/ |k 1/910000/910400/ |p 7 | ||
| 998 | |g 122373448 |a Schlehe, Bettina |m 122373448:Schlehe, Bettina |d 910000 |d 910400 |e 910000PS122373448 |e 910400PS122373448 |k 0/910000/ |k 1/910000/910400/ |p 6 | ||
| 998 | |g 1140255843 |a Shumilov, Anatoliy |m 1140255843:Shumilov, Anatoliy |d 50000 |e 50000PS1140255843 |k 0/50000/ |p 3 | ||
| 998 | |g 1074144465 |a Tsai, Ming-Han |m 1074144465:Tsai, Ming-Han |d 50000 |e 50000PT1074144465 |k 0/50000/ |p 2 | ||
| 998 | |g 1175226084 |a Zyl, Dwain George van |m 1175226084:Zyl, Dwain George van |d 50000 |e 50000PZ1175226084 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1586493752 |e 3047732256 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 23.01.2019"],"recId":"1586493752","type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice","title":"Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice"}],"id":{"doi":["10.1371/journal.ppat.1007464"],"eki":["1586493752"]},"name":{"displayForm":["Dwain G. van Zyl, Ming-Han Tsai, Anatoliy Shumilov, Viktor Schneidt, Rémy Poirey, Bettina Schlehe, Herbert Fluhr, Josef Mautner, Henri-Jacques Delecluse"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"December 6, 2018"}],"relHost":[{"name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2005","publisherPlace":"Lawrence, Kan.","dateIssuedDisp":"2005-","publisher":"PLoS"}],"language":["eng"],"disp":"Public Library of SciencePLoS pathogens","title":[{"title":"PLoS pathogens","title_sort":"PLoS pathogens"}],"id":{"issn":["1553-7374"],"zdb":["2205412-1"],"eki":["501074422"]},"titleAlt":[{"title":"Pathogens"}],"corporate":[{"display":"Public Library of Science","roleDisplay":"VerfasserIn","role":"aut"}],"pubHistory":["1.2005,Sept. -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"501074422","part":{"volume":"14","issue":"12","text":"14 (2018,12) Artikel-Nummer e1007464, 23 Seiten","year":"2018"},"note":["Gesehen am 20.11.2020"]}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Dwain George van","display":"Zyl, Dwain George van","family":"Zyl"},{"display":"Tsai, Ming-Han","roleDisplay":"VerfasserIn","role":"aut","given":"Ming-Han","family":"Tsai"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Anatoliy","display":"Shumilov, Anatoliy","family":"Shumilov"},{"family":"Schlehe","roleDisplay":"VerfasserIn","role":"aut","given":"Bettina","display":"Schlehe, Bettina"},{"display":"Fluhr, Herbert","given":"Herbert","role":"aut","roleDisplay":"VerfasserIn","family":"Fluhr"},{"display":"Delecluse, Henri-Jacques","roleDisplay":"VerfasserIn","role":"aut","given":"Henri-Jacques","family":"Delecluse"}],"language":["eng"]} | ||
| SRT | |a ZYLDWAINGEIMMUNOGENI6201 | ||