Technology, applications, and process challenges of dual chamber systems
Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, an...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2016
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| In: |
Journal of pharmaceutical sciences
Year: 2016, Jahrgang: 105, Heft: 1, Pages: 4-9 |
| ISSN: | 1520-6017 |
| DOI: | 10.1016/j.xphs.2015.11.025 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.xphs.2015.11.025 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022354915001409 
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| Verfasserangaben: | Tobias Werk, Imke S. Ludwig, Joerg Luemkemann, Hanns-Christian Mahler, Joerg Huwyler, Mathias Hafner |
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| 520 | |a Dual-chamber systems provide an option as a drug and device combination product, when home care and emergency lyophilized products are intended. Nevertheless, until today, there are only a few products on the market, due to the challenges and limitations in manufacturability, product formulation, and product stability in a dual-chamber configuration, as well as economic considerations. This review serves to describe currently available dual-chamber systems and to discuss factors to be considered for appropriate selection and establishing fill-finish processes. | ||
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