Cover Image

Towards a blood-based diagnostic panel for bipolar disorder

Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Metho...

Full description

Saved in:
Bibliographic Details
Main Authors: Haenisch, Frieder (Author) , Leweke, F. Markus (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Brain, behavior and immunity
Year: 2015, Volume: 52, Pages: 49-57
ISSN:1090-2139
DOI:10.1016/j.bbi.2015.10.001
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.bbi.2015.10.001
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0889159115300271
Get full text
Author Notes:Frieder Haenisch, Jason D. Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F. Markus Leweke, Matthias Rothermundt, Nico J.M. van Beveren, Benedicto Crespo-Facorro, David W. Niebuhr, David N. Cowan, Natalya S. Weber, Robert H. Yolken, Brenda W.J.H. Penninx, Sabine Bahn

MARC

LEADER 00000caa a2200000 c 4500
001 1586649027
003 DE-627
005 20230427034218.0
007 cr uuu---uuuuu
008 190128r20162015xx |||||o 00| ||eng c
024 7 |a 10.1016/j.bbi.2015.10.001  |2 doi 
035 |a (DE-627)1586649027 
035 |a (DE-576)516649027 
035 |a (DE-599)BSZ516649027 
035 |a (OCoLC)1341034568 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Haenisch, Frieder  |e VerfasserIn  |0 (DE-588)1176460900  |0 (DE-627)1047462958  |0 (DE-576)516648977  |4 aut 
245 1 0 |a Towards a blood-based diagnostic panel for bipolar disorder  |c Frieder Haenisch, Jason D. Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F. Markus Leweke, Matthias Rothermundt, Nico J.M. van Beveren, Benedicto Crespo-Facorro, David W. Niebuhr, David N. Cowan, Natalya S. Weber, Robert H. Yolken, Brenda W.J.H. Penninx, Sabine Bahn 
264 1 |c 2016 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 28.01.2019 
500 |a Available online 13 October 2015 
520 |a Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies. We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC)⩾0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel. Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD. 
534 |c 2015 
650 4 |a Biomarker 
650 4 |a Bipolar disorder 
650 4 |a Diagnostic test 
650 4 |a Differential diagnosis 
650 4 |a Multiplex immunoassay 
700 1 |a Leweke, F. Markus  |e VerfasserIn  |0 (DE-588)1052094287  |0 (DE-627)787796859  |0 (DE-576)407845941  |4 aut 
773 0 8 |i Enthalten in  |t Brain, behavior and immunity  |d Orlando, Fla. [u.a.] : Elsevier, 1987  |g 52(2016), Seite 49-57  |h Online-Ressource  |w (DE-627)254634087  |w (DE-600)1462491-6  |w (DE-576)261631098  |x 1090-2139  |7 nnas  |a Towards a blood-based diagnostic panel for bipolar disorder 
773 1 8 |g volume:52  |g year:2016  |g pages:49-57  |g extent:9  |a Towards a blood-based diagnostic panel for bipolar disorder 
856 4 0 |u http://dx.doi.org/10.1016/j.bbi.2015.10.001  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0889159115300271  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190128 
993 |a Article 
994 |a 2016 
998 |g 1052094287  |a Leweke, F. Markus  |m 1052094287:Leweke, F. Markus  |d 60000  |e 60000PL1052094287  |k 0/60000/  |p 6 
999 |a KXP-PPN1586649027  |e 3049339985 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"9 S."}],"title":[{"title":"Towards a blood-based diagnostic panel for bipolar disorder","title_sort":"Towards a blood-based diagnostic panel for bipolar disorder"}],"person":[{"given":"Frieder","family":"Haenisch","role":"aut","display":"Haenisch, Frieder"},{"given":"F. Markus","family":"Leweke","display":"Leweke, F. Markus","role":"aut"}],"relHost":[{"disp":"Towards a blood-based diagnostic panel for bipolar disorderBrain, behavior and immunity","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Brain, behavior and immunity","title_sort":"Brain, behavior and immunity"}],"part":{"pages":"49-57","text":"52(2016), Seite 49-57","extent":"9","volume":"52","year":"2016"},"pubHistory":["1.1987 -"],"id":{"zdb":["1462491-6"],"issn":["1090-2139"],"eki":["254634087"]},"recId":"254634087","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 22.01.2020"],"origin":[{"dateIssuedDisp":"1987-","publisher":"Elsevier ; Academic Press","publisherPlace":"Orlando, Fla. [u.a.] ; Orlando, Fla.","dateIssuedKey":"1987"}]}],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"2016"}],"note":["Gesehen am 28.01.2019","Available online 13 October 2015"],"id":{"eki":["1586649027"],"doi":["10.1016/j.bbi.2015.10.001"]},"language":["eng"],"name":{"displayForm":["Frieder Haenisch, Jason D. Cooper, Andreas Reif, Sarah Kittel-Schneider, Johann Steiner, F. Markus Leweke, Matthias Rothermundt, Nico J.M. van Beveren, Benedicto Crespo-Facorro, David W. Niebuhr, David N. Cowan, Natalya S. Weber, Robert H. Yolken, Brenda W.J.H. Penninx, Sabine Bahn"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1586649027"} 
SRT |a HAENISCHFRTOWARDSABL2016 

Similar Items