Buchumschlag

The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse

The nucleoside adenosine has been implicated in the regulation of respiration, especially during hypoxia in the newborn. In this study the role of adenosine A1 receptors for the control of respiration was investigated in vivo. To this end, respiration of unrestrained adult and neonatal adenosine A1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: Heitzmann, Dirk (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2016
In: Respiratory physiology & neurobiology
Year: 2015, Jahrgang: 222, Pages: 16-28
ISSN:1878-1519
DOI:10.1016/j.resp.2015.11.005
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.resp.2015.11.005
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S156990481530077X
Volltext
Verfasserangaben:Dirk Heitzmann, Philipp Buehler, Frank Schweda, Michael Georgieff, Richard Warth, Joerg Thomas

MARC

LEADER 00000caa a2200000 c 4500
001 1586668676
003 DE-627
005 20220815094429.0
007 cr uuu---uuuuu
008 190129r20162015xx |||||o 00| ||eng c
024 7 |a 10.1016/j.resp.2015.11.005  |2 doi 
035 |a (DE-627)1586668676 
035 |a (DE-576)516668676 
035 |a (DE-599)BSZ516668676 
035 |a (OCoLC)1341034594 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Heitzmann, Dirk  |d 1973-  |e VerfasserIn  |0 (DE-588)1155025679  |0 (DE-627)1016326297  |0 (DE-576)501389245  |4 aut 
245 1 4 |a The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse  |c Dirk Heitzmann, Philipp Buehler, Frank Schweda, Michael Georgieff, Richard Warth, Joerg Thomas 
264 1 |c 2016 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 29.01.2019 
500 |a Available online 28 November 2015 
500 |a Im Titel ist "1" tiefgestellt 
520 |a The nucleoside adenosine has been implicated in the regulation of respiration, especially during hypoxia in the newborn. In this study the role of adenosine A1 receptors for the control of respiration was investigated in vivo. To this end, respiration of unrestrained adult and neonatal adenosine A1 receptor knockout mice (A1R-/- ) was measured in a plethysmographic device. Under control conditions (21% O2) and mild hypoxia (12-15% O2) no difference of respiratory parameters was observed between adult wildtype (A1R+/+) and A1R-/- mice. Under more severe hypoxia (6-10% O2) A1R+/+ mice showed, after a transient increase of respiration, a decrease of respiration frequency (fR) and tidal volume (VT) leading to a decrease of minute volume (MV). This depression of respiration during severe hypoxia was absent in A1R-/- mice which displayed a stimulated respiration as indicated by the enhancement of MV by some 50-60%. During hypercapnia-hyperoxia (3-10% CO2/97-90 % O2), no obvious differences in respiration of A1R-/- and A1R+/+ was observed. In neonatal mice, the respiratory response to hypoxia was surprisingly similar in both genotypes. However, neonatal A1R-/- mice appeared to have more frequently periods of apnea during hypoxia and in the post-hypoxic control period. In conclusion, these data indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice. 
534 |c 2015 
650 4 |a A receptor knockout 
650 4 |a Adenosine 
650 4 |a HRD 
650 4 |a Hypoxia 
650 4 |a Mouse 
773 0 8 |i Enthalten in  |t Respiratory physiology & neurobiology  |d Amsterdam [u.a.] : Elsevier Science, 2002  |g 222(2016), Seite 16-28  |h Online-Ressource  |w (DE-627)34823113X  |w (DE-600)2079218-9  |w (DE-576)099604337  |x 1878-1519  |7 nnas  |a The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse 
773 1 8 |g volume:222  |g year:2016  |g pages:16-28  |g extent:13  |a The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse 
856 4 0 |u http://dx.doi.org/10.1016/j.resp.2015.11.005  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S156990481530077X  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190129 
993 |a Article 
994 |a 2016 
998 |g 1155025679  |a Heitzmann, Dirk  |m 1155025679:Heitzmann, Dirk  |d 60000  |d 61400  |e 60000PH1155025679  |e 61400PH1155025679  |k 0/60000/  |k 1/60000/61400/  |p 1  |x j 
999 |a KXP-PPN1586668676  |e 3049892536 
BIB |a Y 
SER |a journal 
JSO |a {"recId":"1586668676","language":["eng"],"note":["Gesehen am 29.01.2019","Available online 28 November 2015","Im Titel ist \"1\" tiefgestellt"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"display":"Heitzmann, Dirk","roleDisplay":"VerfasserIn","role":"aut","family":"Heitzmann","given":"Dirk"}],"title":[{"title":"The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse","title_sort":"in vivo respiratory phenotype of the adenosine A1 receptor knockout mouse"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["34823113X"],"zdb":["2079218-9"],"issn":["1878-1519"]},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"2002","publisher":"Elsevier Science","dateIssuedDisp":"2002-"}],"recId":"34823113X","language":["eng"],"note":["Gesehen am 21.02.20"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"The in vivo respiratory phenotype of the adenosine A1 receptor knockout mouseRespiratory physiology & neurobiology","part":{"pages":"16-28","year":"2016","extent":"13","volume":"222","text":"222(2016), Seite 16-28"},"pubHistory":["130.2002 -"],"title":[{"title_sort":"Respiratory physiology & neurobiology","title":"Respiratory physiology & neurobiology"}]}],"physDesc":[{"extent":"13 S."}],"name":{"displayForm":["Dirk Heitzmann, Philipp Buehler, Frank Schweda, Michael Georgieff, Richard Warth, Joerg Thomas"]},"id":{"eki":["1586668676"],"doi":["10.1016/j.resp.2015.11.005"]},"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"2016"}]} 
SRT |a HEITZMANNDINVIVORESP2016 

Ähnliche Einträge