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Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alterations to mT...

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Bibliographic Details
Main Authors: Marin Zapata, Paula Andrea (Author) , Dalmasso, Giovanni (Author) , Brady, Nathan (Author) , Hamacher-Brady, Anne (Author)
Format: Article (Journal)
Language:English
Published: 7 June 2016
In: BMC cancer
Year: 2016, Volume: 16
ISSN:1471-2407
DOI:10.1186/s12885-016-2388-9
Online Access:Verlag, Volltext: http://dx.doi.org/10.1186/s12885-016-2388-9
Verlag, Volltext: https://doi.org/10.1186/s12885-016-2388-9
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Author Notes:Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady and Anne Hamacher-Brady
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Summary:TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alterations to mTOR activity states and changes in TFEB subcellular localization and concentration has not been sufficiently addressed.
Item Description:Gesehen am 29.01.2019
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-016-2388-9

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