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Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alterations to mT...

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Bibliographische Detailangaben
Hauptverfasser: Marin Zapata, Paula Andrea (VerfasserIn) , Dalmasso, Giovanni (VerfasserIn) , Brady, Nathan (VerfasserIn) , Hamacher-Brady, Anne (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 7 June 2016
In: BMC cancer
Year: 2016, Jahrgang: 16
ISSN:1471-2407
DOI:10.1186/s12885-016-2388-9
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1186/s12885-016-2388-9
Verlag, Volltext: https://doi.org/10.1186/s12885-016-2388-9
Volltext
Verfasserangaben:Paula Andrea Marin Zapata, Carsten Jörn Beese, Anja Jünger, Giovanni Dalmasso, Nathan Ryan Brady and Anne Hamacher-Brady
Beschreibung
Zusammenfassung:TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alterations to mTOR activity states and changes in TFEB subcellular localization and concentration has not been sufficiently addressed.
Beschreibung:Gesehen am 29.01.2019
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-016-2388-9

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