Co-assembly of chitosan and phospholipids into hybrid hydrogels
Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A l...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
02.11.2016
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| In: |
Pure and applied chemistry
Year: 2016, Volume: 88, Issue: 9, Pages: 905-916 |
| ISSN: | 1365-3075 |
| DOI: | 10.1515/pac-2016-0708 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1515/pac-2016-0708 Verlag, Volltext: http://www.degruyterbrill.com/view/j/pac.2016.88.issue-9/pac-2016-0708/pac-2016-0708.xml 
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| Author Notes: | Ana C. Mendes, Elhamalsadat Shekarforoush, Christoph Engwer, Sophie R. Beeren, Christian Gorzelanny, Francisco M. Goycoolea and Ioannis S. Chronakis |
| Summary: | Novel hybrid hydrogels were formed by adding chitosan (Ch) to phospholipids (P) self-assembled particles in lactic acid. The effect of the phospholipid concentration on the hydrogel properties was investigated and was observed to affect the rate of hydrogel formation and viscoelastic properties. A lower concentration of phospholipids (0.5% wt/v) in the mixture, facilitates faster network formation as observed by Dynamic Light Scattering, with lower elastic modulus than the hydrogels formed with higher phospholipid content. The nano-porous structure of Ch/P hydrogels, with a diameter of 260±20 nm, as observed by cryo-scanning electron microscopy, facilitated the penetration of water and swelling. Cell studies revealed suitable biocompatibility of the Ch/P hydrogels that can be used within life sciences applications. |
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| Item Description: | Gesehen am 04.02.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1365-3075 |
| DOI: | 10.1515/pac-2016-0708 |