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Location-dependent patient outcome and recurrence patterns in IDH1-wildtype glioblastoma

Recent studies suggest that glioblastomas (GBMs) contacting the subventricular zone (SVZ) as the main adult neurogenic niche confer a dismal prognosis but disregard the unique molecular and prognostic phenotype associated with isocitrate dehydrogenase 1 (IDH1) mutations. We therefore examined locati...

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Hauptverfasser: Jungk, Christine (VerfasserIn) , Warta, Rolf (VerfasserIn) , Mock, Andreas (VerfasserIn) , Friauf, Sara (VerfasserIn) , Capper, David (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Bendszus, Martin (VerfasserIn) , Deimling, Andreas von (VerfasserIn) , Unterberg, Andreas (VerfasserIn) , Herold-Mende, Christel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 January 2019
In: Cancers
Year: 2019, Jahrgang: 11, Heft: 1
ISSN:2072-6694
DOI:10.3390/cancers11010122
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3390/cancers11010122
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/11/1/122
Volltext
Verfasserangaben:Christine Jungk, Rolf Warta, Andreas Mock, Sara Friauf, Bettina Hug, David Capper, Amir Abdollahi, Jürgen Debus, Martin Bendszus, Andreas von Deimling, Andreas Unterberg and Christel Herold-Mende
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Zusammenfassung:Recent studies suggest that glioblastomas (GBMs) contacting the subventricular zone (SVZ) as the main adult neurogenic niche confer a dismal prognosis but disregard the unique molecular and prognostic phenotype associated with isocitrate dehydrogenase 1 (IDH1) mutations. We therefore examined location-dependent prognostic factors, growth, and recurrence patterns in a consecutive cohort of 285 IDH1-wildtype GBMs. Based on pre-operative contrast-enhanced MRI, patients were allotted to four location-dependent groups with (SVZ+; groups I, II) and without (SVZ&minus;; groups III, IV) SVZ involvement or with (cortex+; groups I, III) and without (cortex&minus;; groups II, IV) cortical involvement and compared for demographic, treatment, imaging, and survival data at first diagnosis and recurrence. SVZ involvement was associated with lower Karnofsky performance score (p < 0.001), lower frequency of complete resections at first diagnosis (p < 0.0001), and lower non-surgical treatment intensity at recurrence (p < 0.001). Multivariate survival analysis employing a Cox proportional hazards model identified SVZ involvement as an independent prognosticator of inferior overall survival (p < 0.001) and survival after relapse (p = 0.041). In contrast, multifocal growth at first diagnosis (p = 0.031) and recurrence (p < 0.001), as well as distant recurrences (p < 0.0001), was more frequent in cortex+ GBMs. These findings offer the prospect for location-tailored prognostication and treatment based on factors assessable on pre-operative MRI.
Beschreibung:Gesehen am 06.02.2019
Beschreibung:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers11010122

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