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The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition

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<p>Coagulation and complement regulators belong to two interactive systems constituting emerging mechanisms of diabetic nephropathy. Thrombomodulin (TM) regulates both coagulation and complement activation, in part through discrete domains. TM’s lectin like domain dampens complement activation...

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Main Authors: Wang, Hongjie (Author) , Bock, Fabian (Author) , Kashif, Muhammed (Author) , Bierhaus, Angelika (Author) , Nawroth, Peter Paul (Author) , Kirschfink, Michael (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Thrombosis and haemostasis
Year: 2012, Volume: 108, Issue: 12, Pages: 1141-1153
ISSN:2567-689X
DOI:10.1160/TH12-07-0460
Online Access:Verlag, Volltext: http://dx.doi.org/10.1160/TH12-07-0460
Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1160/TH12-07-0460
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Author Notes:Hongjie Wang, Ilya Vinnikov, Khurrum Shahzad, Fabian Bock, Satish Ranjan, Juliane Wolter, Muhammed Kashif, Jun Oh, Angelika Bierhaus, Peter Nawroth, Michael Kirschfink, Edward M. Conway, Thati Madhusudhan, Berend Isermann
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The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition by Wang, Hongjie (Author) , Vinnikov, Ilya A. (Author) , Shahzad Hussain, Khurrum (Author) ,


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