Insulin-like growth factor system in neuroblastoma tumorigenesis and apoptosis: potential diagnostic and therapeutic perspectives
Apoptosis is a cell death program which is modulated by a variety of factors including growth factors, signal transduction molecules and inducers of gene expression or DNA replication. Of particular interest is Type I insulin-like growth factor receptor which contains a tyrosine kinase domain linked...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
Hormone and metabolic research
Year: 1999, Jahrgang: 31, Heft: 2/3, Pages: 138-141 |
| ISSN: | 1439-4286 |
| DOI: | 10.1055/s-2007-978711 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1055/s-2007-978711 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-978711 
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| Verfasserangaben: | W. Zumkeller, M. Schwab |
MARC
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| 520 | |a Apoptosis is a cell death program which is modulated by a variety of factors including growth factors, signal transduction molecules and inducers of gene expression or DNA replication. Of particular interest is Type I insulin-like growth factor receptor which contains a tyrosine kinase domain linked to the ras-raf-MAPK cascade. This receptor has antiapoptotic effects in a number of in vivo and in vitro models, thus making IGF-I-R a potential target for gene therapy. Particularly the growth of neuroblastoma depends on IGFs which exert their effect through the Type I IGF receptor. This review highlights the role of the IGF-system in neuroblastoma and points at possible modulators with the aim of inducing differentiation or apoptosis of tumor cells. | ||
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