Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias
Objective The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of patients present...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
International journal of cardiology
Year: 2019, Jahrgang: 277, Pages: 118-124 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2018.11.030 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.ijcard.2018.11.030 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167527318345728 
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| Verfasserangaben: | Tobias Schupp, Michael Behnes, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Christel Weiß, Christoph Nienaber, Siegfried Lang, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin |
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| 245 | 1 | 0 | |a Prognostic impact of beta-blocker compared to combined amiodarone therapy secondary to ventricular tachyarrhythmias |c Tobias Schupp, Michael Behnes, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Christel Weiß, Christoph Nienaber, Siegfried Lang, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin |
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| 520 | |a Objective The study sought to assess the prognostic impact of treatment with beta-blocker (BB) compared to combined BB plus amiodarone (BB-AMIO) on long-term survival in patients surviving ventricular tachyarrhythmias on admission. Background Data regarding the prognostic outcome of patients presenting with ventricular tachyarrhythmias treated with BB and BB-AMIO is limited. Methods A large retrospective registry was used including consecutive patients surviving index episodes of ventricular tachyarrhythmias from 2002 to 2016. Patients treated with BB were compared to patients with BB-AMIO. The primary prognostic endpoint was long-term all-cause death at 3years. Kaplan-Meier, multivariable Cox regression and propensity score matching analyses were applied. Results A total of 1354 patients was included, 85% treated with BB, 15% with BB-AMIO. Within the unmatched real-life cohort, uni- and multivariable Cox regression models revealed BB associated with improved long-term survival compared to BB-AMIO (univariable: HR=0.550; p=0.001, multivariable: HR=0.712; statistical trend, p=0.052). After propensity-score matching (n=186 matched pairs), BB therapy was still associated with improved survival compared to BB-AMIO (mortality rate 18% versus 26%; log rank p=0.042; HR=0.634; 95% CI=0.407-0.988; p=0.044). Prognostic superiority of BB was mainly observed in patients with LVEF≥35% (HR=0.463; 95% CI=0.215-0.997; p=0.049) and in those without atrial fibrillation (non-AF) (HR=0.415; 95% CI=0.202-0.852; p=0.017). Conclusion BB therapy is associated with improved secondary long-term prognosis compared to BB-AMIO in patients surviving index episodes of ventricular tachyarrhythmias. | ||
| 650 | 4 | |a Amiodarone | |
| 650 | 4 | |a Beta-blocker | |
| 650 | 4 | |a ICD | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Ventricular fibrillation | |
| 650 | 4 | |a Ventricular tachycardia | |
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