Clinical prognostic variables in young patients (under 40 years) with hepatitis B virus-associated hepatocellular carcinoma
OBJECTIVE: The aim of this study was to determine the impact of hepatocelluar carcinoma (HCC) screening in chronic hepatitis B patients who did not meet the current screening recommendations. METHODS: Patients who were admitted to Bellevue Hospital Center with HCC were assessed for risk factors, cir...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 January 2012
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| In: |
Journal of digestive diseases
Year: 2012, Volume: 13, Issue: 4, Pages: 214-218 |
| ISSN: | 1751-2980 |
| DOI: | 10.1111/j.1751-2980.2012.00577.x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/j.1751-2980.2012.00577.x Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-2980.2012.00577.x 
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| Author Notes: | Qin Wang, Wei Luan, Gerald A. Villanueva, Nuh N. Rahbari, Herman T. Yee, Fotini Manizate, Spiros P. Hiotis |
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| 245 | 1 | 0 | |a Clinical prognostic variables in young patients (under 40 years) with hepatitis B virus-associated hepatocellular carcinoma |c Qin Wang, Wei Luan, Gerald A. Villanueva, Nuh N. Rahbari, Herman T. Yee, Fotini Manizate, Spiros P. Hiotis |
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| 520 | |a OBJECTIVE: The aim of this study was to determine the impact of hepatocelluar carcinoma (HCC) screening in chronic hepatitis B patients who did not meet the current screening recommendations. METHODS: Patients who were admitted to Bellevue Hospital Center with HCC were assessed for risk factors, cirrhosis and tumor-specific factors. Eligibility for liver transplantation or resection with favorable outcome was determined by applying Milan criteria. RESULTS: In all 93 patients were diagnosed with hepatitis B virus (HBV)-associated HCC, 18 of whom were under 40 years. Cirrhosis was infrequently associated with HCC in this group, with most cancers occurring in non-cirrhotic patients (12/18, 66.7%). No patient developed HCC outside the American Association for the Study of Liver Diseases (AASLD) cancer screening recommendations (young age, non-cirrhotic) were eligible for liver transplantation or resection with favorable outcomes (within Milan criteria). However, HCC patients who were diagnosed within AASLD screening recommendations did meet Milan criteria in 17.3% (14/81) patients. CONCLUSIONS: Current guidelines for HCC screening in patients with HBV may lead to a delay in diagnosis in non-cirrhotic patients under 40 years. Consideration should be given to modifying current recommendations to advocate entering HBV patients into a cancer-screening program at young age. | ||
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