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In-depth functional diagnostics of mouse models by single-flash and flicker electroretinograms without adapting background illumination

Electroretinograms (ERGs) are commonly recorded at the cornea for an assessment of the functional status of the retina in mouse models. Full-field ERGs can be elicited by single-flash as well as flicker light stimulation although in most laboratories flicker ERGs are recorded much less frequently th...

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Bibliographic Details
Main Authors: Tanimoto, Naoyuki (Author) , Hammes, Hans-Peter (Author)
Format: Chapter/Article
Language:English
Published: 2016
In: Retinal Degenerative Diseases
Year: 2016, Pages: 619-625
DOI:10.1007/978-3-319-17121-0_82
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/978-3-319-17121-0_82
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Author Notes:Naoyuki Tanimoto, Stylianos Michalakis, Bernhard H. F. Weber, Christian A. Wahl-Schott, Hans-Peter Hammes, Mathias W. Seeliger

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520 |a Electroretinograms (ERGs) are commonly recorded at the cornea for an assessment of the functional status of the retina in mouse models. Full-field ERGs can be elicited by single-flash as well as flicker light stimulation although in most laboratories flicker ERGs are recorded much less frequently than singleflash ERGs. Whereas conventional single-flash ERGs contain information about layers, i.e., outer and inner retina, flicker ERGs permit functional assessment of the vertical pathways of the retina, i.e., rod system, cone ON-pathway, and cone OFF-pathway, when the responses are evoked at a relatively high luminance (0.5 log cd s/m2) with varying frequency (from 0.5 to 30 Hz) without any adapting background illumination. Therefore, both types of ERGs complement an in-depth functional characterization of the mouse retina, allowing for a discrimination of an underlying functional pathology. Here, we introduce the systematic interpretation of the single-flash and flicker ERGs by demonstrating several different patterns of functional phenotype in genetic mouse models, in which photoreceptors and/or bipolar cells are primarily or secondarily affected. 
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