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Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo

Endocytosed nicotinic acetylcholine receptors (CHRN) are degraded via macroautophagy/autophagy during atrophic conditions and are accompanied by the autophagic regulator protein SH3GLB1. The present study addressed the functional role of SH3GLB1 on CHRN trafficking and its implementation. We found a...

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Main Authors: Wild, Franziska (Author) , Khan, Muzamil Majid (Author) , Rudolf, Rüdiger (Author)
Format: Article (Journal)
Language:English
Published: 01 Nov 2016
In: Autophagy
Year: 2016, Volume: 12, Issue: 12, Pages: 2300-2310
ISSN:1554-8635
DOI:10.1080/15548627.2016.1234564
Online Access:Verlag, Volltext: http://dx.doi.org/10.1080/15548627.2016.1234564
Verlag, Volltext: https://doi.org/10.1080/15548627.2016.1234564
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Author Notes:Franziska Wild, Muzamil Majid Khan, Tatjana Straka, Rüdiger Rudolf

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